Phosphatidylcholine bearing 6,6-dideuterated oleic acid: A useful solid-state 2H NMR probe for investigating membrane properties

Jin Cui, Sébastien Lethu, Tomokazu Yasuda, Shigeru Matsuoka, Nobuaki Matsumori, Fuminori Sato, Michio Murata

研究成果: Contribution to journalArticle査読

9 被引用数 (Scopus)

抄録

Lipid organization has been at the center of research on lipid rafts. Dioleoylphosphatidylcholine (DOPC) is a typical unsaturated lipid. Very few studies have reported its thermodynamics in raft-like membranes. Herein, we have developed a highly efficient synthetic method for [C6-2H2] oleic acid, and newly synthesized [C6-2H2] DOPC. In raft-like oriented bilayers, [C6-2H2] DOPC shows clear phase separation and characteristic phase behavior at various temperature. It has been successfully utilized for the comparison of membrane properties between sphingomyelin (SM) and dihydrosphingomyelin (DHSM) membranes.

本文言語英語
ページ(範囲)203-206
ページ数4
ジャーナルBioorganic and Medicinal Chemistry Letters
25
2
DOI
出版ステータス出版済み - 1 15 2015
外部発表はい

All Science Journal Classification (ASJC) codes

  • 生化学
  • 分子医療
  • 分子生物学
  • 薬科学
  • 創薬
  • 臨床生化学
  • 有機化学

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