Phosphatidylserine and phosphatidylcholine-containing liposomes inhibit amyloid β and interferon-γ-induced microglial activation

Sadayuki Hashioka, Youn Hee Han, Shunsuke Fujii, Takahiro Kato, Akira Monji, Hideo Utsumi, Makoto Sawada, Hiroshi Nakanishi, Shigenobu Kanba

研究成果: ジャーナルへの寄稿学術誌査読

66 被引用数 (Scopus)

抄録

There is increasing evidence that microglial activation is one of the major pathogenic factors for Alzheimer's disease (AD) and the inhibition of the inflammatory activation of the microglia thus appears to be neuroprotective and a potentially useful treatment for AD. Phospholipids such as phosphatidylserine (PS) and phosphatidylcholine (PC) have been reported to modulate the immune function of phagocytes. In addition, PS has been reported to be a nootropics that can be used as nonprescription memory or cognitive enhancers. We therefore evaluated the effects of liposomes, which comprise both PS and PC (PS/PC liposomes), on the microglial production of tumor necrosis factor-α (TNF-α), nitric oxide (NO), and superoxide ({radical dot}O2-) induced by amyloid β (Aβ) and interferon-γ (IFN-γ). Pretreatment of microglia with PS/PC liposomes considerably inhibited the TNF-α, NO and {radical dot}O2- production induced by Aβ/IFN-γ. These results suggest that PS/PC liposomes have both neuroprotective and antioxidative properties through the inhibition of microglial activation, thus supporting the nootropic and antidementia effect of PS.

本文言語英語
ページ(範囲)945-954
ページ数10
ジャーナルFree Radical Biology and Medicine
42
7
DOI
出版ステータス出版済み - 4月 1 2007

!!!All Science Journal Classification (ASJC) codes

  • 生化学
  • 生理学(医学)

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