Phosphatidylserine synthase I and II of mammalian cells

Osamu Kuge, Masahiro Nishijima

研究成果: ジャーナルへの寄稿総説査読

71 被引用数 (Scopus)

抄録

Phosphatidylserine (PtdSer) in mammalian cells is synthesized through an exchange of free L-serine for the base moiety of pre-existing phospholipids. Studies on PtdSer biosynthesis in Chinese hamster ovary (CHO) cells have suggested that the serine base-exchange is catalyzed by at least two different enzymes; one, named PtdSer synthase I (PSS I), uses phosphatidylcholine (PtdCho) and possibly phosphatidylethanolamine (PtdEtn) as phosphatidyl donors for the serine base-exchange, and the other, named PtdSer synthase II (PSS II), uses PtdEtn but not PtdCho as a phosphatidyl donor. Recently, cDNAs of the PSS I and II have been isolated from CHO-K1 cells. This review will briefly describe the current understanding of PtdSer synthases of mammalian cells, mainly CHO cells.

本文言語英語
ページ(範囲)151-156
ページ数6
ジャーナルBiochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism
1348
1-2
DOI
出版ステータス出版済み - 9月 4 1997
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 生物理学
  • 生化学
  • 内分泌学

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