Phosphorylation of the Sendai virus C proteins

Dana D. Hendricks, Etsuro Ono, Jerome M. Sever, Kailash C. Gupta

研究成果: Contribution to journalArticle査読

12 被引用数 (Scopus)

抄録

We show that the Sendai virus C' and C proteins exist as both phosphorylated and nonphosphorylated forms, while the Y1 and Y2 proteins are not phosphorylated in virus-infected cells. Phosphorylation occurs primarily on serine residues, most likely at the N-terminus of the C' and C proteins. Phosphatases PP1 and PP2A significantly modulate the phosphorylation status of the C proteins as evidenced by okadaic acid inhibition of these phosphatases. The other Sendai virus proteins including the cotranslationally expressed P protein are not necessary for the appropriate phosphorylation of the C' and C proteins. Differential phosphorylation and potential for the modulation of phosphorylation suggests regulatory functions for the C proteins.

本文言語英語
論文番号71615
ページ(範囲)471-474
ページ数4
ジャーナルVirology
197
1
DOI
出版ステータス出版済み - 11 1993
外部発表はい

All Science Journal Classification (ASJC) codes

  • ウイルス学

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