Phosphorylation of the Sendai virus C proteins

Dana D. Hendricks, Etsuro Ono, Jerome M. Sever, Kailash C. Gupta

研究成果: Contribution to journalArticle

12 引用 (Scopus)

抜粋

We show that the Sendai virus C' and C proteins exist as both phosphorylated and nonphosphorylated forms, while the Y1 and Y2 proteins are not phosphorylated in virus-infected cells. Phosphorylation occurs primarily on serine residues, most likely at the N-terminus of the C' and C proteins. Phosphatases PP1 and PP2A significantly modulate the phosphorylation status of the C proteins as evidenced by okadaic acid inhibition of these phosphatases. The other Sendai virus proteins including the cotranslationally expressed P protein are not necessary for the appropriate phosphorylation of the C' and C proteins. Differential phosphorylation and potential for the modulation of phosphorylation suggests regulatory functions for the C proteins.

元の言語英語
記事番号71615
ページ(範囲)471-474
ページ数4
ジャーナルVirology
197
発行部数1
DOI
出版物ステータス出版済み - 11 1993
外部発表Yes

All Science Journal Classification (ASJC) codes

  • Virology

フィンガープリント Phosphorylation of the Sendai virus C proteins' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用

    Hendricks, D. D., Ono, E., Sever, J. M., & Gupta, K. C. (1993). Phosphorylation of the Sendai virus C proteins. Virology, 197(1), 471-474. [71615]. https://doi.org/10.1006/viro.1993.1615