Phosphoserine phosphatase is a novel prognostic biomarker on chromosome 7 in colorectal cancer

Kuniaki Sato, Takaaki Masuda, Qingjiang Hu, Taro Tobo, Shinya Kidogami, Yushi Ogawa, Tomoko Saito, Sho Nambara, Hisateru Komatsu, Hidenari Hirata, Shotaro Sakimura, Ryutaro Uchi, Naoki Hayashi, Tomohiro Iguchi, Hidetoshi Eguchi, Shuhei Ito, Takashi Nakagawa, Koshi Mimori

研究成果: ジャーナルへの寄稿記事

8 引用 (Scopus)

抄録

Background/Aim: Amplification of chromosome 7p (Ch.7p) is common in colorectal cancer (CRC). The aim of this study was to identify potential driver genes on Ch.7p that are overexpressed due to DNA copy number amplification and determine their clinical significance in CRC. Materials and Methods: We identified phosphoserine phosphatase (PSPH) as a potential driver gene using a CRC dataset from The Cancer Genome Atlas (TCGA) using a bioinformatics approach. The expression of PSPH in 124 primary CRCs was examined by quantitative reverse transcription polymerase chain reaction (PCR) and immunohistochemistry. The biological effect of PSPH expression was explored by Gene Set Enrichment Analysis (GSEA) using the TCGA dataset. Results: PSPH was overexpressed in tumor tissues and PSPH positively correlated with depth of invasion and distant metastasis. On multivariate analysis, high PSPH expression was an independent poor prognostic factor. These results were supported by GSEA. Conclusion: PSPH could be a novel prognostic biomarker with malignant potential on Ch.7p in CRC.

元の言語英語
ページ(範囲)2365-2371
ページ数7
ジャーナルAnticancer research
37
発行部数5
DOI
出版物ステータス出版済み - 5 1 2017

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Chromosomes, Human, Pair 7
Colorectal Neoplasms
Biomarkers
Atlases
Genes
Genome
Neoplasms
phosphoserine phosphatase
Computational Biology
Reverse Transcription
Multivariate Analysis
Chromosomes
Immunohistochemistry
Neoplasm Metastasis
Polymerase Chain Reaction
DNA

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

これを引用

Phosphoserine phosphatase is a novel prognostic biomarker on chromosome 7 in colorectal cancer. / Sato, Kuniaki; Masuda, Takaaki; Hu, Qingjiang; Tobo, Taro; Kidogami, Shinya; Ogawa, Yushi; Saito, Tomoko; Nambara, Sho; Komatsu, Hisateru; Hirata, Hidenari; Sakimura, Shotaro; Uchi, Ryutaro; Hayashi, Naoki; Iguchi, Tomohiro; Eguchi, Hidetoshi; Ito, Shuhei; Nakagawa, Takashi; Mimori, Koshi.

:: Anticancer research, 巻 37, 番号 5, 01.05.2017, p. 2365-2371.

研究成果: ジャーナルへの寄稿記事

Sato, K, Masuda, T, Hu, Q, Tobo, T, Kidogami, S, Ogawa, Y, Saito, T, Nambara, S, Komatsu, H, Hirata, H, Sakimura, S, Uchi, R, Hayashi, N, Iguchi, T, Eguchi, H, Ito, S, Nakagawa, T & Mimori, K 2017, 'Phosphoserine phosphatase is a novel prognostic biomarker on chromosome 7 in colorectal cancer', Anticancer research, 巻. 37, 番号 5, pp. 2365-2371. https://doi.org/10.21873/anticanres.11574
Sato, Kuniaki ; Masuda, Takaaki ; Hu, Qingjiang ; Tobo, Taro ; Kidogami, Shinya ; Ogawa, Yushi ; Saito, Tomoko ; Nambara, Sho ; Komatsu, Hisateru ; Hirata, Hidenari ; Sakimura, Shotaro ; Uchi, Ryutaro ; Hayashi, Naoki ; Iguchi, Tomohiro ; Eguchi, Hidetoshi ; Ito, Shuhei ; Nakagawa, Takashi ; Mimori, Koshi. / Phosphoserine phosphatase is a novel prognostic biomarker on chromosome 7 in colorectal cancer. :: Anticancer research. 2017 ; 巻 37, 番号 5. pp. 2365-2371.
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abstract = "Background/Aim: Amplification of chromosome 7p (Ch.7p) is common in colorectal cancer (CRC). The aim of this study was to identify potential driver genes on Ch.7p that are overexpressed due to DNA copy number amplification and determine their clinical significance in CRC. Materials and Methods: We identified phosphoserine phosphatase (PSPH) as a potential driver gene using a CRC dataset from The Cancer Genome Atlas (TCGA) using a bioinformatics approach. The expression of PSPH in 124 primary CRCs was examined by quantitative reverse transcription polymerase chain reaction (PCR) and immunohistochemistry. The biological effect of PSPH expression was explored by Gene Set Enrichment Analysis (GSEA) using the TCGA dataset. Results: PSPH was overexpressed in tumor tissues and PSPH positively correlated with depth of invasion and distant metastasis. On multivariate analysis, high PSPH expression was an independent poor prognostic factor. These results were supported by GSEA. Conclusion: PSPH could be a novel prognostic biomarker with malignant potential on Ch.7p in CRC.",
author = "Kuniaki Sato and Takaaki Masuda and Qingjiang Hu and Taro Tobo and Shinya Kidogami and Yushi Ogawa and Tomoko Saito and Sho Nambara and Hisateru Komatsu and Hidenari Hirata and Shotaro Sakimura and Ryutaro Uchi and Naoki Hayashi and Tomohiro Iguchi and Hidetoshi Eguchi and Shuhei Ito and Takashi Nakagawa and Koshi Mimori",
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T1 - Phosphoserine phosphatase is a novel prognostic biomarker on chromosome 7 in colorectal cancer

AU - Sato, Kuniaki

AU - Masuda, Takaaki

AU - Hu, Qingjiang

AU - Tobo, Taro

AU - Kidogami, Shinya

AU - Ogawa, Yushi

AU - Saito, Tomoko

AU - Nambara, Sho

AU - Komatsu, Hisateru

AU - Hirata, Hidenari

AU - Sakimura, Shotaro

AU - Uchi, Ryutaro

AU - Hayashi, Naoki

AU - Iguchi, Tomohiro

AU - Eguchi, Hidetoshi

AU - Ito, Shuhei

AU - Nakagawa, Takashi

AU - Mimori, Koshi

PY - 2017/5/1

Y1 - 2017/5/1

N2 - Background/Aim: Amplification of chromosome 7p (Ch.7p) is common in colorectal cancer (CRC). The aim of this study was to identify potential driver genes on Ch.7p that are overexpressed due to DNA copy number amplification and determine their clinical significance in CRC. Materials and Methods: We identified phosphoserine phosphatase (PSPH) as a potential driver gene using a CRC dataset from The Cancer Genome Atlas (TCGA) using a bioinformatics approach. The expression of PSPH in 124 primary CRCs was examined by quantitative reverse transcription polymerase chain reaction (PCR) and immunohistochemistry. The biological effect of PSPH expression was explored by Gene Set Enrichment Analysis (GSEA) using the TCGA dataset. Results: PSPH was overexpressed in tumor tissues and PSPH positively correlated with depth of invasion and distant metastasis. On multivariate analysis, high PSPH expression was an independent poor prognostic factor. These results were supported by GSEA. Conclusion: PSPH could be a novel prognostic biomarker with malignant potential on Ch.7p in CRC.

AB - Background/Aim: Amplification of chromosome 7p (Ch.7p) is common in colorectal cancer (CRC). The aim of this study was to identify potential driver genes on Ch.7p that are overexpressed due to DNA copy number amplification and determine their clinical significance in CRC. Materials and Methods: We identified phosphoserine phosphatase (PSPH) as a potential driver gene using a CRC dataset from The Cancer Genome Atlas (TCGA) using a bioinformatics approach. The expression of PSPH in 124 primary CRCs was examined by quantitative reverse transcription polymerase chain reaction (PCR) and immunohistochemistry. The biological effect of PSPH expression was explored by Gene Set Enrichment Analysis (GSEA) using the TCGA dataset. Results: PSPH was overexpressed in tumor tissues and PSPH positively correlated with depth of invasion and distant metastasis. On multivariate analysis, high PSPH expression was an independent poor prognostic factor. These results were supported by GSEA. Conclusion: PSPH could be a novel prognostic biomarker with malignant potential on Ch.7p in CRC.

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