@article{a6e446900f8e42f48a72a7fc1c1ca8c6,
title = "Photo-reactive oligodeoxynucleotide-embedded nanovesicles (PROsomes) with switchable stability for efficient cellular uptake and gene knockdown",
abstract = "A photo-responsive nanovesicle is fabricated by polyion complex (PIC) formation between poly(ethylene glycol) (PEG)-block-polypeptides and photo-reactive oligodeoxynucleotides (PROs)/anti-sense oligonucleotides (ASOs). The ultraviolet (UV) light triggers reversible crosslinking between PROs and ASOs in the vesicular membrane, providing the nanovesicle with switchable stability under physiological conditions. The resulting nanovesicle allows efficient cellular internalization, leading to significant UV-triggered gene knockdown in cultured cells. This journal is ",
author = "Kim, {Beob Soo} and Mitsuru Naito and Rimpei Kamegawa and Kim, {Hyun Jin} and Ryo Iizuka and Takashi Funatsu and Shingo Ueno and Takanori Ichiki and Akihiro Kishimura and Kanjiro Miyata",
note = "Funding Information: This research was financially supported by the Center of Innovation (COI) Program (Grant Number: JPMJCE1305) and Research Complex Program from the Japan Science and Technology Agency (JST), Grant-in-Aid for Scientific Research of MEXT of Japan (JSPS KAKENHI Grant Number: 18K19900 for KM), and JSPS Core-to-Core Program (Grant Number: JPJSCCA20170007). We are grateful to Mr H. Hoshi, The University of Tokyo and the Research Hub for Advanced Nano Characterization at The University of Tokyo for the valuable support in TEM observation. Publisher Copyright: {\textcopyright} The Royal Society of Chemistry.",
year = "2020",
month = aug,
day = "25",
doi = "10.1039/d0cc01750g",
language = "English",
volume = "56",
pages = "9477--9480",
journal = "Chemical Communications",
issn = "1359-7345",
publisher = "Royal Society of Chemistry",
number = "66",
}