Physical and functional interaction between WRNIP1 and RAD18

Akari Yoshimura, Masayuki Seki, Makoto Kanamori, Satoshi Tateishi, Toshiki Tsurimoto, Shusuke Tada, Takemi Enomoto

研究成果: ジャーナルへの寄稿記事

18 引用 (Scopus)

抄録

WRN interacting protein 1 (WRNIP1) was originally identified as a protein that interacts with the Werner syndrome responsible gene product (WRN). WRNIP1 is a highly conserved protein from E. coli to humans. Genetic studies in budding yeast suggested that the yeast orthlog of WRNIP1, Mgs1, may function in a DNA damage tolerance pathway that is similar to, but distinct from, the template-switch damage avoidance pathway involving Rad6, Rad18, Rad5, Mms2, and Ubc13. Here we report that human WRNIP1 binds in an ATP dependent manner to both forked DNA that mimics stalled replication forks and to template/primer DNA. We found that WRNIP1 interacts physically with RAD18 and interferes with the binding of RAD18 to forked DNA and to template/primer DNA. In contrast, RAD18 enhances the binding of WRNIP1 to these DNAs, suggesting that WRNIP1 targets DNA bound by RAD18.

元の言語英語
ページ(範囲)171-178
ページ数8
ジャーナルGenes and Genetic Systems
84
発行部数2
DOI
出版物ステータス出版済み - 7 14 2009

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Proteins
DNA Primers
DNA
Werner Syndrome
Saccharomycetales
Escherichia coli Proteins
DNA Damage
Adenosine Triphosphate
Yeasts
Genes
human WRN protein

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics

これを引用

Yoshimura, A., Seki, M., Kanamori, M., Tateishi, S., Tsurimoto, T., Tada, S., & Enomoto, T. (2009). Physical and functional interaction between WRNIP1 and RAD18. Genes and Genetic Systems, 84(2), 171-178. https://doi.org/10.1266/ggs.84.171

Physical and functional interaction between WRNIP1 and RAD18. / Yoshimura, Akari; Seki, Masayuki; Kanamori, Makoto; Tateishi, Satoshi; Tsurimoto, Toshiki; Tada, Shusuke; Enomoto, Takemi.

:: Genes and Genetic Systems, 巻 84, 番号 2, 14.07.2009, p. 171-178.

研究成果: ジャーナルへの寄稿記事

Yoshimura, A, Seki, M, Kanamori, M, Tateishi, S, Tsurimoto, T, Tada, S & Enomoto, T 2009, 'Physical and functional interaction between WRNIP1 and RAD18', Genes and Genetic Systems, 巻. 84, 番号 2, pp. 171-178. https://doi.org/10.1266/ggs.84.171
Yoshimura A, Seki M, Kanamori M, Tateishi S, Tsurimoto T, Tada S その他. Physical and functional interaction between WRNIP1 and RAD18. Genes and Genetic Systems. 2009 7 14;84(2):171-178. https://doi.org/10.1266/ggs.84.171
Yoshimura, Akari ; Seki, Masayuki ; Kanamori, Makoto ; Tateishi, Satoshi ; Tsurimoto, Toshiki ; Tada, Shusuke ; Enomoto, Takemi. / Physical and functional interaction between WRNIP1 and RAD18. :: Genes and Genetic Systems. 2009 ; 巻 84, 番号 2. pp. 171-178.
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