Physiological and pathological relevance of secretory microRNAs and a perspective on their clinical application

Takeshi Katsuda, Shingo Ikeda, Yusuke Yoshioka, Nobuyoshi Kosaka, Masaki Kawamata, Takahiro Ochiya

研究成果: ジャーナルへの寄稿評論記事

7 引用 (Scopus)

抄録

MicroRNAs (miRNAs) have attracted significant attention because of their important roles in a variety of physiological and pathological processes. Recent studies have shown that many cell types secrete miRNAs by packaging them into lipid-bilayered small vesicles called exosomes. Furthermore, exosomal miRNAs travel between cells, exert their RNAi effects in the recipient cells, and play important roles in various biological processes. In this article, we will summarize and describe the latest studies on exosomal miRNAs by focusing on their roles in cancer progression, immune regulation, and tissue repair. We will also provide a perspective on the clinical applications of this research field.

元の言語英語
ページ(範囲)365-373
ページ数9
ジャーナルBiological chemistry
395
発行部数4
DOI
出版物ステータス出版済み - 4 1 2014
外部発表Yes

Fingerprint

MicroRNAs
Physiological Phenomena
Exosomes
Biological Phenomena
Product Packaging
Pathologic Processes
RNA Interference
Packaging
Repair
Tissue
Lipids
Research
Neoplasms

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Clinical Biochemistry

これを引用

Physiological and pathological relevance of secretory microRNAs and a perspective on their clinical application. / Katsuda, Takeshi; Ikeda, Shingo; Yoshioka, Yusuke; Kosaka, Nobuyoshi; Kawamata, Masaki; Ochiya, Takahiro.

:: Biological chemistry, 巻 395, 番号 4, 01.04.2014, p. 365-373.

研究成果: ジャーナルへの寄稿評論記事

Katsuda, Takeshi ; Ikeda, Shingo ; Yoshioka, Yusuke ; Kosaka, Nobuyoshi ; Kawamata, Masaki ; Ochiya, Takahiro. / Physiological and pathological relevance of secretory microRNAs and a perspective on their clinical application. :: Biological chemistry. 2014 ; 巻 395, 番号 4. pp. 365-373.
@article{67fb31a872074001903c379b4ecea382,
title = "Physiological and pathological relevance of secretory microRNAs and a perspective on their clinical application",
abstract = "MicroRNAs (miRNAs) have attracted significant attention because of their important roles in a variety of physiological and pathological processes. Recent studies have shown that many cell types secrete miRNAs by packaging them into lipid-bilayered small vesicles called exosomes. Furthermore, exosomal miRNAs travel between cells, exert their RNAi effects in the recipient cells, and play important roles in various biological processes. In this article, we will summarize and describe the latest studies on exosomal miRNAs by focusing on their roles in cancer progression, immune regulation, and tissue repair. We will also provide a perspective on the clinical applications of this research field.",
author = "Takeshi Katsuda and Shingo Ikeda and Yusuke Yoshioka and Nobuyoshi Kosaka and Masaki Kawamata and Takahiro Ochiya",
year = "2014",
month = "4",
day = "1",
doi = "10.1515/hsz-2013-0222",
language = "English",
volume = "395",
pages = "365--373",
journal = "Biological Chemistry",
issn = "1431-6730",
publisher = "Walter de Gruyter GmbH & Co. KG",
number = "4",

}

TY - JOUR

T1 - Physiological and pathological relevance of secretory microRNAs and a perspective on their clinical application

AU - Katsuda, Takeshi

AU - Ikeda, Shingo

AU - Yoshioka, Yusuke

AU - Kosaka, Nobuyoshi

AU - Kawamata, Masaki

AU - Ochiya, Takahiro

PY - 2014/4/1

Y1 - 2014/4/1

N2 - MicroRNAs (miRNAs) have attracted significant attention because of their important roles in a variety of physiological and pathological processes. Recent studies have shown that many cell types secrete miRNAs by packaging them into lipid-bilayered small vesicles called exosomes. Furthermore, exosomal miRNAs travel between cells, exert their RNAi effects in the recipient cells, and play important roles in various biological processes. In this article, we will summarize and describe the latest studies on exosomal miRNAs by focusing on their roles in cancer progression, immune regulation, and tissue repair. We will also provide a perspective on the clinical applications of this research field.

AB - MicroRNAs (miRNAs) have attracted significant attention because of their important roles in a variety of physiological and pathological processes. Recent studies have shown that many cell types secrete miRNAs by packaging them into lipid-bilayered small vesicles called exosomes. Furthermore, exosomal miRNAs travel between cells, exert their RNAi effects in the recipient cells, and play important roles in various biological processes. In this article, we will summarize and describe the latest studies on exosomal miRNAs by focusing on their roles in cancer progression, immune regulation, and tissue repair. We will also provide a perspective on the clinical applications of this research field.

UR - http://www.scopus.com/inward/record.url?scp=84896754362&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84896754362&partnerID=8YFLogxK

U2 - 10.1515/hsz-2013-0222

DO - 10.1515/hsz-2013-0222

M3 - Review article

C2 - 24323889

AN - SCOPUS:84896754362

VL - 395

SP - 365

EP - 373

JO - Biological Chemistry

JF - Biological Chemistry

SN - 1431-6730

IS - 4

ER -