抄録
MicroRNAs (miRNAs) have attracted significant attention because of their important roles in a variety of physiological and pathological processes. Recent studies have shown that many cell types secrete miRNAs by packaging them into lipid-bilayered small vesicles called exosomes. Furthermore, exosomal miRNAs travel between cells, exert their RNAi effects in the recipient cells, and play important roles in various biological processes. In this article, we will summarize and describe the latest studies on exosomal miRNAs by focusing on their roles in cancer progression, immune regulation, and tissue repair. We will also provide a perspective on the clinical applications of this research field.
| 元の言語 | 英語 |
|---|---|
| ページ（範囲） | 365-373 |
| ページ数 | 9 |
| ジャーナル | Biological chemistry |
| 巻 | 395 |
| 発行部数 | 4 |
| DOI | |
| 出版物ステータス | 出版済み - 4 1 2014 |
| 外部発表 | Yes |
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All Science Journal Classification (ASJC) codes
- Biochemistry
- Molecular Biology
- Clinical Biochemistry
これを引用
Physiological and pathological relevance of secretory microRNAs and a perspective on their clinical application. / Katsuda, Takeshi; Ikeda, Shingo; Yoshioka, Yusuke; Kosaka, Nobuyoshi; Kawamata, Masaki; Ochiya, Takahiro.
：: Biological chemistry, 巻 395, 番号 4, 01.04.2014, p. 365-373.研究成果: ジャーナルへの寄稿 › 評論記事
}
TY - JOUR
T1 - Physiological and pathological relevance of secretory microRNAs and a perspective on their clinical application
AU - Katsuda, Takeshi
AU - Ikeda, Shingo
AU - Yoshioka, Yusuke
AU - Kosaka, Nobuyoshi
AU - Kawamata, Masaki
AU - Ochiya, Takahiro
PY - 2014/4/1
Y1 - 2014/4/1
N2 - MicroRNAs (miRNAs) have attracted significant attention because of their important roles in a variety of physiological and pathological processes. Recent studies have shown that many cell types secrete miRNAs by packaging them into lipid-bilayered small vesicles called exosomes. Furthermore, exosomal miRNAs travel between cells, exert their RNAi effects in the recipient cells, and play important roles in various biological processes. In this article, we will summarize and describe the latest studies on exosomal miRNAs by focusing on their roles in cancer progression, immune regulation, and tissue repair. We will also provide a perspective on the clinical applications of this research field.
AB - MicroRNAs (miRNAs) have attracted significant attention because of their important roles in a variety of physiological and pathological processes. Recent studies have shown that many cell types secrete miRNAs by packaging them into lipid-bilayered small vesicles called exosomes. Furthermore, exosomal miRNAs travel between cells, exert their RNAi effects in the recipient cells, and play important roles in various biological processes. In this article, we will summarize and describe the latest studies on exosomal miRNAs by focusing on their roles in cancer progression, immune regulation, and tissue repair. We will also provide a perspective on the clinical applications of this research field.
UR - http://www.scopus.com/inward/record.url?scp=84896754362&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84896754362&partnerID=8YFLogxK
U2 - 10.1515/hsz-2013-0222
DO - 10.1515/hsz-2013-0222
M3 - Review article
C2 - 24323889
AN - SCOPUS:84896754362
VL - 395
SP - 365
EP - 373
JO - Biological Chemistry
JF - Biological Chemistry
SN - 1431-6730
IS - 4
ER -