PICT1 expression is a poor prognostic factor in non-small cell lung cancer

Kyoko Okamura, Koichi Takayama, Kohichi Kawahara, Taishi Harada, Miki Nishio, Kohei Otsubo, Kayo Ijichi, Mikihiro Kohno, Eiji Iwama, Akiko Fujii, Keiichi Ota, Takaomi Koga, Tatsuro Okamoto, Akira Suzuki, Yoichi Nakanishi

研究成果: ジャーナルへの寄稿記事

10 引用 (Scopus)

抄録

PICT1 is a key regulator of the MDM2-TP53 pathway. High mRNA expression levels of PICT1 are associated with poor prognosis in several cancers with wild-type TP53. In this study, we identified the PICT1 protein expression profile in non-small cell lung cancer (NSCLC) with wild-type TP53 in the nucleolus and cytoplasm, and revealed the relationship between PICT1 expression and patient clinicopathological factors. PICT1 expression in the tumor cells of 96 NSCLC patients with wild-type TP53 was evaluated by immunohistochemistry. Forty-three of 96 (44.8%) NSCLC samples were positive for nucleolar PICT1, while 40/96 (41.7%) NSCLC samples were positive for cytoplasmic PICT1. There was no correlation between nucleolar PICT1 expression and clinicopathological factors. However, cytoplasmic PICT1 expression was significantly correlated with sex, smoking history, differentiation, lymphatic invasion and pathological stage. In multivariate analysis, lymphatic invasion was significantly associated with cytoplasmic PICT1 expression (hazard ratio: 5.02, P = 0.026). We scrutinized PICT1 expression in samples of NSCLC with wild-type TP53, and showed a correlation between cytoplasmic PICT1 expression and several clinicopathological factors in these patients. Our results indicate that cytoplasmic PICT1 expression is a poor prognostic factor and is associated with tumor progression via lymphatic invasion in these patients.

元の言語英語
ページ(範囲)375-382
ページ数8
ジャーナルOncoscience
1
発行部数5
DOI
出版物ステータス出版済み - 1 1 2014

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Non-Small Cell Lung Carcinoma
Neoplasms
Cytoplasm
Multivariate Analysis
Smoking
History
Immunohistochemistry
Messenger RNA
Proteins

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

これを引用

Okamura, K., Takayama, K., Kawahara, K., Harada, T., Nishio, M., Otsubo, K., ... Nakanishi, Y. (2014). PICT1 expression is a poor prognostic factor in non-small cell lung cancer. Oncoscience, 1(5), 375-382. https://doi.org/10.18632/oncoscience.43

PICT1 expression is a poor prognostic factor in non-small cell lung cancer. / Okamura, Kyoko; Takayama, Koichi; Kawahara, Kohichi; Harada, Taishi; Nishio, Miki; Otsubo, Kohei; Ijichi, Kayo; Kohno, Mikihiro; Iwama, Eiji; Fujii, Akiko; Ota, Keiichi; Koga, Takaomi; Okamoto, Tatsuro; Suzuki, Akira; Nakanishi, Yoichi.

:: Oncoscience, 巻 1, 番号 5, 01.01.2014, p. 375-382.

研究成果: ジャーナルへの寄稿記事

Okamura, K, Takayama, K, Kawahara, K, Harada, T, Nishio, M, Otsubo, K, Ijichi, K, Kohno, M, Iwama, E, Fujii, A, Ota, K, Koga, T, Okamoto, T, Suzuki, A & Nakanishi, Y 2014, 'PICT1 expression is a poor prognostic factor in non-small cell lung cancer', Oncoscience, 巻. 1, 番号 5, pp. 375-382. https://doi.org/10.18632/oncoscience.43
Okamura K, Takayama K, Kawahara K, Harada T, Nishio M, Otsubo K その他. PICT1 expression is a poor prognostic factor in non-small cell lung cancer. Oncoscience. 2014 1 1;1(5):375-382. https://doi.org/10.18632/oncoscience.43
Okamura, Kyoko ; Takayama, Koichi ; Kawahara, Kohichi ; Harada, Taishi ; Nishio, Miki ; Otsubo, Kohei ; Ijichi, Kayo ; Kohno, Mikihiro ; Iwama, Eiji ; Fujii, Akiko ; Ota, Keiichi ; Koga, Takaomi ; Okamoto, Tatsuro ; Suzuki, Akira ; Nakanishi, Yoichi. / PICT1 expression is a poor prognostic factor in non-small cell lung cancer. :: Oncoscience. 2014 ; 巻 1, 番号 5. pp. 375-382.
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abstract = "PICT1 is a key regulator of the MDM2-TP53 pathway. High mRNA expression levels of PICT1 are associated with poor prognosis in several cancers with wild-type TP53. In this study, we identified the PICT1 protein expression profile in non-small cell lung cancer (NSCLC) with wild-type TP53 in the nucleolus and cytoplasm, and revealed the relationship between PICT1 expression and patient clinicopathological factors. PICT1 expression in the tumor cells of 96 NSCLC patients with wild-type TP53 was evaluated by immunohistochemistry. Forty-three of 96 (44.8{\%}) NSCLC samples were positive for nucleolar PICT1, while 40/96 (41.7{\%}) NSCLC samples were positive for cytoplasmic PICT1. There was no correlation between nucleolar PICT1 expression and clinicopathological factors. However, cytoplasmic PICT1 expression was significantly correlated with sex, smoking history, differentiation, lymphatic invasion and pathological stage. In multivariate analysis, lymphatic invasion was significantly associated with cytoplasmic PICT1 expression (hazard ratio: 5.02, P = 0.026). We scrutinized PICT1 expression in samples of NSCLC with wild-type TP53, and showed a correlation between cytoplasmic PICT1 expression and several clinicopathological factors in these patients. Our results indicate that cytoplasmic PICT1 expression is a poor prognostic factor and is associated with tumor progression via lymphatic invasion in these patients.",
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AU - Takayama, Koichi

AU - Kawahara, Kohichi

AU - Harada, Taishi

AU - Nishio, Miki

AU - Otsubo, Kohei

AU - Ijichi, Kayo

AU - Kohno, Mikihiro

AU - Iwama, Eiji

AU - Fujii, Akiko

AU - Ota, Keiichi

AU - Koga, Takaomi

AU - Okamoto, Tatsuro

AU - Suzuki, Akira

AU - Nakanishi, Yoichi

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