Piperine, a pepper ingredient, improves the hepatic increase in free fatty acids caused by 2,3,7,8-tetrachlorodibenzo-p-dioxin

Takumi Ishida, Mizuho Ishizaki, Siho Tsutsumi, Yuji Ishii, Hideyuki Yamada

研究成果: ジャーナルへの寄稿記事

5 引用 (Scopus)

抄録

Dioxins, such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), are ubiquitous environmental pollutants. The variety of adverse effects produced by dioxins are a serious problem because they may affect humans and wild animals through the food chain. In this study, we examined the possible protective effects of piperine, which is a major alkaloid in black pepper (Piper nigrum Linn.) and long pepper (Piper longum Linn.), on the toxic effects of TCDD in C57BL/6J mice. The repeated administration of high doses (30 and 45 mg/kg, 14 days, p.o.) of piperine alone produced a weak agonistic effect on the aryl hydrocarbon receptor, which was evaluated based on the increase in hepatic ethoxyresorufin O-deethylase (EROD) activity. No such effect was observed at the lowest dose (15mg piperine/kg). However, while coadministration (20 mg/kg, 28 days, p.o.) of piperine with TCDD had no effect on TCDD-induced wasting syndrome, it improved the hepatic accumulation of free fatty acids produced by TCDD. In relation to this, the hepatic accumulation of triglycerides by TCDD also tended to be reduced by piperine. Despite the above effects, piperine failed to reduce the increase in hepatic EROD activity and lipid peroxidation produced by TCDD. These results suggest that piperine is a candidate to improve disorders of lipid metabolism produced by dioxins, although the mechanism remains to be clarified.

元の言語英語
ページ(範囲)551-558
ページ数8
ジャーナルJournal of Health Science
54
発行部数5
DOI
出版物ステータス出版済み - 10 1 2008

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piperine
Nonesterified Fatty Acids
Liver
Dioxins
Piper nigrum
Piper
Cytochrome P-450 CYP1A1
Lipid Metabolism Disorders
Wasting Syndrome
Aryl Hydrocarbon Receptors
Environmental Pollutants
Wild Animals
Food Chain
Poisons
Polychlorinated Dibenzodioxins
1,4-dioxin
Inbred C57BL Mouse
Alkaloids
Lipid Peroxidation
Animals

All Science Journal Classification (ASJC) codes

  • Toxicology
  • Health, Toxicology and Mutagenesis

これを引用

Piperine, a pepper ingredient, improves the hepatic increase in free fatty acids caused by 2,3,7,8-tetrachlorodibenzo-p-dioxin. / Ishida, Takumi; Ishizaki, Mizuho; Tsutsumi, Siho; Ishii, Yuji; Yamada, Hideyuki.

:: Journal of Health Science, 巻 54, 番号 5, 01.10.2008, p. 551-558.

研究成果: ジャーナルへの寄稿記事

Ishida, Takumi ; Ishizaki, Mizuho ; Tsutsumi, Siho ; Ishii, Yuji ; Yamada, Hideyuki. / Piperine, a pepper ingredient, improves the hepatic increase in free fatty acids caused by 2,3,7,8-tetrachlorodibenzo-p-dioxin. :: Journal of Health Science. 2008 ; 巻 54, 番号 5. pp. 551-558.
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abstract = "Dioxins, such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), are ubiquitous environmental pollutants. The variety of adverse effects produced by dioxins are a serious problem because they may affect humans and wild animals through the food chain. In this study, we examined the possible protective effects of piperine, which is a major alkaloid in black pepper (Piper nigrum Linn.) and long pepper (Piper longum Linn.), on the toxic effects of TCDD in C57BL/6J mice. The repeated administration of high doses (30 and 45 mg/kg, 14 days, p.o.) of piperine alone produced a weak agonistic effect on the aryl hydrocarbon receptor, which was evaluated based on the increase in hepatic ethoxyresorufin O-deethylase (EROD) activity. No such effect was observed at the lowest dose (15mg piperine/kg). However, while coadministration (20 mg/kg, 28 days, p.o.) of piperine with TCDD had no effect on TCDD-induced wasting syndrome, it improved the hepatic accumulation of free fatty acids produced by TCDD. In relation to this, the hepatic accumulation of triglycerides by TCDD also tended to be reduced by piperine. Despite the above effects, piperine failed to reduce the increase in hepatic EROD activity and lipid peroxidation produced by TCDD. These results suggest that piperine is a candidate to improve disorders of lipid metabolism produced by dioxins, although the mechanism remains to be clarified.",
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