Pituitary growth hormone suppression reduces resistin expression and enhances insulin effectiveness: Relationship with caloric restriction

Takuya Chiba, Haruyoshi Yamaza, Toshimitsu Komatsu, Masahiko Nakayama, Satoshi Fujita, Hiroko Hayashi, Yoshikazu Higami, Isao Shimokawa

研究成果: ジャーナルへの寄稿記事

21 引用 (Scopus)

抄録

Caloric restriction (CR) retards various age-dependent disorders, increases lifespan, and improves insulin activity in laboratory animals. Recently, adipocytes were found to act together as an active endocrine organ that produces various hormones called adipocytokines. The peripheral and central activities of these adipocytokines have been suggested to mediate the anti-aging effects of CR. Here, we tested this notion by analyzing the effect of CR and suppression of growth hormone/insulin-like growth factor-I (GH/IGF-I) axis on the expression of resistin, adiponectin, and adipsin genes by rat white adipose tissue (WAT). We found that CR and GH/IGF-I suppression markedly downregulated resistin gene expression. We also found plasma resistin levels correlated positively with pituitary GH mRNA expression levels. Our observations suggest that CR reduces resistin expression and increases insulin effectiveness in a GH/IGF-I-dependent manner. The beneficial effects of CR and GH/IGF-I suppression appear to be mediated, at least in part, by changes in glucose metabolism that result from reductions in plasma resistin levels.

元の言語英語
ページ(範囲)595-600
ページ数6
ジャーナルExperimental Gerontology
43
発行部数6
DOI
出版物ステータス出版済み - 6 1 2008
外部発表Yes

Fingerprint

Resistin
Caloric Restriction
Growth Hormone
Insulin
Insulin-Like Growth Factor I
Adipokines
Complement Factor D
Plasmas
White Adipose Tissue
Adiponectin
Laboratory Animals
Adipocytes
Metabolism
Gene expression
Rats
Animals
Down-Regulation
Genes
Aging of materials
Hormones

All Science Journal Classification (ASJC) codes

  • Ageing
  • Medicine(all)

これを引用

Pituitary growth hormone suppression reduces resistin expression and enhances insulin effectiveness : Relationship with caloric restriction. / Chiba, Takuya; Yamaza, Haruyoshi; Komatsu, Toshimitsu; Nakayama, Masahiko; Fujita, Satoshi; Hayashi, Hiroko; Higami, Yoshikazu; Shimokawa, Isao.

:: Experimental Gerontology, 巻 43, 番号 6, 01.06.2008, p. 595-600.

研究成果: ジャーナルへの寄稿記事

Chiba, Takuya ; Yamaza, Haruyoshi ; Komatsu, Toshimitsu ; Nakayama, Masahiko ; Fujita, Satoshi ; Hayashi, Hiroko ; Higami, Yoshikazu ; Shimokawa, Isao. / Pituitary growth hormone suppression reduces resistin expression and enhances insulin effectiveness : Relationship with caloric restriction. :: Experimental Gerontology. 2008 ; 巻 43, 番号 6. pp. 595-600.
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AU - Fujita, Satoshi

AU - Hayashi, Hiroko

AU - Higami, Yoshikazu

AU - Shimokawa, Isao

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