Plasma d-dimer level as a mortality predictor in patients with advanced or recurrent colorectal cancer

Manabu Yamamoto, Keiji Yoshinaga, Ayumi Matsuyama, Tokiomi Iwasa, Atsushi Osoegawa, Eiji Tsujita, Yoichi Yamashita, Shinichi Tsutsui, Teruyoshi Ishida

研究成果: ジャーナルへの寄稿学術誌査読

46 被引用数 (Scopus)

抄録

Objective: Plasma D-dimer levels are elevated in patients with a variety of solid tumors. Recently, it has been reported that the level before curative surgery is a prognostic factor for colorectal cancer (CRC). We investigated whether the plasma D-dimer level before systemic chemotherapies is a predictor for advanced or recurrent unresectable CRC. Methods: This study included 42 patients treated with systemic chemotherapies for advanced or recurrent unresectable CRC. Variables including clinicopathological factors, plasma D-dimer levels and the modified Glasgow Prognostic Factor Score (mGPS) were evaluated. Results: The plasma D-dimer level was closely related to the mGPS. Survival was shorter for patients with plasma D-dimer levels >5 μg/ml than for those with lower levels. Compared with an mGPS of 0 or 1, an mGPS of 2 was predictive of poor prognosis (p < 0.0001). Old age, advanced stage, plasma D-dimer level and mGPS were significantly associated with mortality, but plasma D-dimer level was the only independent risk factor in multivariate analysis, and was significant related to the clinical response to chemotherapy (p < 0.05). Conclusions: Survival was significantly shorter in patients with elevated plasma D-dimer levels having advanced or recurrent CRC. The plasma D-dimer level before systemic chemotherapies was an independent mortality predictor.

本文言語英語
ページ(範囲)10-15
ページ数6
ジャーナルOncology (Switzerland)
83
1
DOI
出版ステータス出版済み - 7月 1 2012
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 腫瘍学
  • 癌研究

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