Plasma interleukin-6 and tumor necrosis factor-α can predict coronary endothelial dysfunction in hypertensive patients

Masanao Naya, Takahiro Tsukamoto, Koichi Morita, Chietsugu Katoh, Tomoo Furumoto, Satoshi Fujii, Nagara Tamaki, Hiroyuki Tsutsui

研究成果: ジャーナルへの寄稿学術誌査読

73 被引用数 (Scopus)


Coronary endothelial function is impaired in hypertension; however, the severity of this impairment varies among patients. We aimed to identify the predictors of coronary endothelial dysfunction among clinical variables related to hypertension and atherosclerosis. Twenty-seven untreated, uncomplicated essential hypertensive patients and 10 age-matched healthy controls were studied prospectively. Myocardial blood flow (MBF) was measured by using 15O-water positron emission tomography (PET) at rest and during a cold pressor test (CPT). Coronary vascular resistance (CVR) during CPT was used as a marker of coronary endothelial function. Serum low density lipoprotein (LDL) cholesterol, high density lipoprotein (HDL) cholesterol, triglycerldes, malondlaldehyde-LDL, homeostasis model assessment, high-sensitivity C-reactive protein (hs-CRP), and plasma interleukin-6 (IL-6) and tumor necrosis factor (TNF)-α were also measured. CVR during CPT was significantly higher In hypertensive patients than in healthy controls (114±26 vs. 94±12 mmHg/[mL/g/min]; p<0.05). By univariate analysis, CVR during CPT was correlated with LDL cholesterol (r=0.38, p<0.05), IL-6 (r=0.46, p<0.02), and TNF-α (r=0.39, p<0.05) in hypertensive patients. By multivariate analysis, IL-6 and TNF-α were significant independent predictors of CVR during CPT. Elevated plasma IL-6 and TNF-α levels were independent predictors of coronary endothelial dysfunction in hypertensive patients. These results suggest that plasma IL-6 and TNF-α might be useful for identifying the high risk subgroup of hypertensive patients with coronary endothelial dysfuncti rovide an important clue to link systemic inflammation to the development of coronary atherosclerosis.

ジャーナルHypertension Research
出版ステータス出版済み - 6月 2007

!!!All Science Journal Classification (ASJC) codes

  • 内科学
  • 生理学
  • 循環器および心血管医学


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