Plasmid deoxyribonucleic acid and translucent-to-opaque variation in Mycobacterium intracellulare 103

Y. Mizuguchi, M. Fukunaga, H. Taniguchi

研究成果: Contribution to journalArticle査読

31 被引用数 (Scopus)

抄録

After treatment with mitomycin C and other antibacterial agents, a translucent, smooth-colony-forming mycobacterium, isolated from sputum and designated as M. intracellulare strain 103, gave rise to variants forming opaque colonies. These opaque variants were more sensitive streptomycin, kanamycin, viomycin, and rifampin than were the wild-type translucent variants. Plasmid deoxyribonucleic acids taken from translucent strain cells and from cells of certain opaque variants were analyzed by agarose gel electrophoresis. Two plasmids of molecular weights of approximately 2 X 106 and 50 X 106, respectively, were found in the wild-type translucent cells; one of them, the 2 X 106-molecular-weight plasmid, was always missing from deoxyribonucleic acids of the opaque variant cells. The results suggested that translucent colonial appearance and antibiotic resistance of the strain are plasmid-determined functions.

本文言語英語
ページ(範囲)656-659
ページ数4
ジャーナルJournal of bacteriology
146
2
出版ステータス出版済み - 1981

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Molecular Biology

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