Platelet aggregability after endoscopic intravariceal injection of 5 per cent ethanolamine oleate into oesophageal varices

H. Yamaga, M. Hashizume, S. Kitano, H. Higashi, K. Sugimachi

研究成果: ジャーナルへの寄稿記事

2 引用 (Scopus)

抄録

Platelet aggregability and the coagulative and fibrinolytic systems were examined in 45 patients who underwent endoscopic injection sclerotherapy for oesophageal varices. Five per cent ethanolamine oleate, the sclerosant used, was injected into the oesophageal varices. There were significant increases in the concentrations of fibrinopeptide A, fibrinopeptide B‐β‐15–42 and fibrin degradation products‐E after the sclerotherapy. At 1 h after the sclerotherapy the mean(s.e.m.) platelet aggregation was significantly suppressed to 71·9(4·2) per cent of that before the treatment (P <0·01). There was a gradual recovery within 1 week to the same level seen before the sclerotherapy. Thomboxane B2 and 6‐keto‐prostaglandin F, both stable products of thromboxane A2 and prostacyclin respectively, showed significant temporary increases after the sclerotherapy (P <0·01). The peak increase in the level of thromboxane B2 was noted within 1 h after the sclerotherapy and earlier than that for 6‐keto‐prostaglandin F. This increased ratio of prostacyclin and thromboxane A2 may be related to the marked limitation in platelet aggregation.

元の言語英語
ページ(範囲)939-942
ページ数4
ジャーナルBritish Journal of Surgery
76
発行部数9
DOI
出版物ステータス出版済み - 9 1989

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Sclerotherapy
Esophageal and Gastric Varices
Blood Platelets
Injections
Thromboxane A2
Epoprostenol
Platelet Aggregation
Fibrinopeptide A
Sclerosing Solutions
Thromboxane B2
Fibrin
ethanolamine oleate

All Science Journal Classification (ASJC) codes

  • Surgery

これを引用

Platelet aggregability after endoscopic intravariceal injection of 5 per cent ethanolamine oleate into oesophageal varices. / Yamaga, H.; Hashizume, M.; Kitano, S.; Higashi, H.; Sugimachi, K.

:: British Journal of Surgery, 巻 76, 番号 9, 09.1989, p. 939-942.

研究成果: ジャーナルへの寄稿記事

Yamaga, H. ; Hashizume, M. ; Kitano, S. ; Higashi, H. ; Sugimachi, K. / Platelet aggregability after endoscopic intravariceal injection of 5 per cent ethanolamine oleate into oesophageal varices. :: British Journal of Surgery. 1989 ; 巻 76, 番号 9. pp. 939-942.
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