Platelet aggregation and coagulation in the pathogenesis of diabetic retinopathy in rats

T. Ishibashi, K. Tanaka, Y. Taniguchi

研究成果: Contribution to journalArticle査読

53 被引用数 (Scopus)

抄録

Fifty male rats were made diabetic by a single injection of streptozotocin and were killed at periods varying from 1 to 12 mo. Ten saline-injected rats and three rats treated with 3-O-methylglucose and streptozotocin served as controls. Intraluminal changes in retinal vessels were studied by electron microscopy. In diabetic rats maintained for 9-12 mo, microthrombus formation was observed in the various sized retinal vessels at the histologic and ultrastructural level. The microthrombi were mainly composed of aggregated platelets and fibrin strands. However, there was no definite evidence of detachment or loss of the endothelial cells. This microthrombus formation may play an important role in the development of diabetic retinopathy.

本文言語英語
ページ(範囲)601-606
ページ数6
ジャーナルDiabetes
30
7
DOI
出版ステータス出版済み - 1981

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

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