Poly- and perfluoroalkyl substances in maternal serum: Method development and application in Pilot Study of the Japan Environment and Children's Study

Shoji F. Nakayama, Tomohiko Isobe, Miyuki Iwai-Shimada, Yayoi Kobayashi, Yukiko Nishihama, Yu Taniguchi, Makiko Sekiyama, Takehiro Michikawa, Shin Yamazaki, Hiroshi Nitta, Masako Oda, Hiroshi Mitsubuchi, Masafumi Sanefuji, Shouichi Ohga, Nathan Mise, Akihiko Ikegami, Reiko Suga, Masayuki Shimono

研究成果: ジャーナルへの寄稿記事

抜粋

Poly- and perfluoroalkyl substances (PFAS) have been investigated in a number of cohort studies due to concern over their adverse health effects. The aim of this study was to develop a reliable, high throughput and cost-effective analytical method for a broad range of PFAS in human serum. Protein precipitation, automatic solid phase extraction (SPE) pre-treatment and column-switching LC-MS/MS were employed. The optimised and validated method was then used to analyse the levels of 28 PFAS in 339 maternal serum samples from Pilot Study of the Japan Environment and Children's Study. Perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), perfluoroundecanoic acid (PFUnA) and perfluorooctane sulphonic acid (PFOS) were detected in all 339 samples at median (range) concentrations of 1.9 (0.46–15), 1.5 (0.32–10), 1.3 (0.25–4.5) and 3.7 (0.43–15) ng/ml, respectively. These levels are comparable to those reported in previous studies using samples collected from various parts of the world. With a few exceptions, the remainder of the PFAS examined had lower detection rates but were found at concentrations similar to those reported in previous studies. The sensitivity and throughput ability of the method developed here are sufficient for its application in a large-scale biomonitoring study.

元の言語英語
記事番号460933
ジャーナルJournal of Chromatography A
1618
DOI
出版物ステータス出版済み - 5 10 2020

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry
  • Organic Chemistry

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  • これを引用

    Nakayama, S. F., Isobe, T., Iwai-Shimada, M., Kobayashi, Y., Nishihama, Y., Taniguchi, Y., Sekiyama, M., Michikawa, T., Yamazaki, S., Nitta, H., Oda, M., Mitsubuchi, H., Sanefuji, M., Ohga, S., Mise, N., Ikegami, A., Suga, R., & Shimono, M. (2020). Poly- and perfluoroalkyl substances in maternal serum: Method development and application in Pilot Study of the Japan Environment and Children's Study. Journal of Chromatography A, 1618, [460933]. https://doi.org/10.1016/j.chroma.2020.460933