Polybrominated diphenyl ethers from the Indonesian sponge Lamellodysidea herbacea

Novriyandi Hanif, Junichi Tanaka, Andi Setiawan, Agus Trianto, Nicole J. De Voogd, Anggia Murni, Chiaki Tanaka, Tatsuo Higa

研究成果: ジャーナルへの寄稿記事

31 引用 (Scopus)

抄録

Four new (1-4) and 10 known polybrominated diphenyl ethers (5-14) have been isolated from the title sponge. The structures of the new entities were elucidated by interpretation of spectroscopic data and chemical transformations. These metabolites showed potent antimicrobial activity against Bacillus subtilis and moderate/weak cytotoxicity against NBT-T2 rat bladder epithelial cells. The major constituent 14 was treated under debromination conditions to give eight derivatives, which were subjected to a structure-activity relationship study. The results indicated that the presence of two phenolic hydroxyl groups and bromines at C-2 and/or C-5, as in 2, is important for the exhibition of antibacterial activity.

元の言語英語
ページ(範囲)432-435
ページ数4
ジャーナルJournal of Natural Products
70
発行部数3
DOI
出版物ステータス出版済み - 3 1 2007

Fingerprint

Halogenated Diphenyl Ethers
Bromine
Porifera
Bacilli
Structure-Activity Relationship
Cytotoxicity
Metabolites
Bacillus subtilis
Hydroxyl Radical
Rats
Urinary Bladder
Epithelial Cells
Derivatives

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

これを引用

Hanif, N., Tanaka, J., Setiawan, A., Trianto, A., De Voogd, N. J., Murni, A., ... Higa, T. (2007). Polybrominated diphenyl ethers from the Indonesian sponge Lamellodysidea herbacea. Journal of Natural Products, 70(3), 432-435. https://doi.org/10.1021/np0605081

Polybrominated diphenyl ethers from the Indonesian sponge Lamellodysidea herbacea. / Hanif, Novriyandi; Tanaka, Junichi; Setiawan, Andi; Trianto, Agus; De Voogd, Nicole J.; Murni, Anggia; Tanaka, Chiaki; Higa, Tatsuo.

:: Journal of Natural Products, 巻 70, 番号 3, 01.03.2007, p. 432-435.

研究成果: ジャーナルへの寄稿記事

Hanif, N, Tanaka, J, Setiawan, A, Trianto, A, De Voogd, NJ, Murni, A, Tanaka, C & Higa, T 2007, 'Polybrominated diphenyl ethers from the Indonesian sponge Lamellodysidea herbacea', Journal of Natural Products, 巻. 70, 番号 3, pp. 432-435. https://doi.org/10.1021/np0605081
Hanif N, Tanaka J, Setiawan A, Trianto A, De Voogd NJ, Murni A その他. Polybrominated diphenyl ethers from the Indonesian sponge Lamellodysidea herbacea. Journal of Natural Products. 2007 3 1;70(3):432-435. https://doi.org/10.1021/np0605081
Hanif, Novriyandi ; Tanaka, Junichi ; Setiawan, Andi ; Trianto, Agus ; De Voogd, Nicole J. ; Murni, Anggia ; Tanaka, Chiaki ; Higa, Tatsuo. / Polybrominated diphenyl ethers from the Indonesian sponge Lamellodysidea herbacea. :: Journal of Natural Products. 2007 ; 巻 70, 番号 3. pp. 432-435.
@article{bbe0fe878e70411888e9612fae9789c3,
title = "Polybrominated diphenyl ethers from the Indonesian sponge Lamellodysidea herbacea",
abstract = "Four new (1-4) and 10 known polybrominated diphenyl ethers (5-14) have been isolated from the title sponge. The structures of the new entities were elucidated by interpretation of spectroscopic data and chemical transformations. These metabolites showed potent antimicrobial activity against Bacillus subtilis and moderate/weak cytotoxicity against NBT-T2 rat bladder epithelial cells. The major constituent 14 was treated under debromination conditions to give eight derivatives, which were subjected to a structure-activity relationship study. The results indicated that the presence of two phenolic hydroxyl groups and bromines at C-2 and/or C-5, as in 2, is important for the exhibition of antibacterial activity.",
author = "Novriyandi Hanif and Junichi Tanaka and Andi Setiawan and Agus Trianto and {De Voogd}, {Nicole J.} and Anggia Murni and Chiaki Tanaka and Tatsuo Higa",
year = "2007",
month = "3",
day = "1",
doi = "10.1021/np0605081",
language = "English",
volume = "70",
pages = "432--435",
journal = "Journal of Natural Products",
issn = "0163-3864",
publisher = "American Chemical Society",
number = "3",

}

TY - JOUR

T1 - Polybrominated diphenyl ethers from the Indonesian sponge Lamellodysidea herbacea

AU - Hanif, Novriyandi

AU - Tanaka, Junichi

AU - Setiawan, Andi

AU - Trianto, Agus

AU - De Voogd, Nicole J.

AU - Murni, Anggia

AU - Tanaka, Chiaki

AU - Higa, Tatsuo

PY - 2007/3/1

Y1 - 2007/3/1

N2 - Four new (1-4) and 10 known polybrominated diphenyl ethers (5-14) have been isolated from the title sponge. The structures of the new entities were elucidated by interpretation of spectroscopic data and chemical transformations. These metabolites showed potent antimicrobial activity against Bacillus subtilis and moderate/weak cytotoxicity against NBT-T2 rat bladder epithelial cells. The major constituent 14 was treated under debromination conditions to give eight derivatives, which were subjected to a structure-activity relationship study. The results indicated that the presence of two phenolic hydroxyl groups and bromines at C-2 and/or C-5, as in 2, is important for the exhibition of antibacterial activity.

AB - Four new (1-4) and 10 known polybrominated diphenyl ethers (5-14) have been isolated from the title sponge. The structures of the new entities were elucidated by interpretation of spectroscopic data and chemical transformations. These metabolites showed potent antimicrobial activity against Bacillus subtilis and moderate/weak cytotoxicity against NBT-T2 rat bladder epithelial cells. The major constituent 14 was treated under debromination conditions to give eight derivatives, which were subjected to a structure-activity relationship study. The results indicated that the presence of two phenolic hydroxyl groups and bromines at C-2 and/or C-5, as in 2, is important for the exhibition of antibacterial activity.

UR - http://www.scopus.com/inward/record.url?scp=34247098861&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34247098861&partnerID=8YFLogxK

U2 - 10.1021/np0605081

DO - 10.1021/np0605081

M3 - Article

VL - 70

SP - 432

EP - 435

JO - Journal of Natural Products

JF - Journal of Natural Products

SN - 0163-3864

IS - 3

ER -