Poly(ethylene glycol) Hydrogels with a Boronic Acid Monomer via Molecular Imprinting for Selective Removal of Quinic Acid Gamma-Lactone in Coffee

Eisuke Kanao, Yuko Tsuchiya, Kei Tanaka, Yusuke Masuda, Tetsuya Tanigawa, Toyohiro Naito, Tomoharu Sano, Takuya Kubo, Koji Otsuka

研究成果: ジャーナルへの寄稿学術誌査読

2 被引用数 (Scopus)

抄録

We developed molecularly imprinted polymers (MIPs) with a poly(ethylene glycol) (PEG)-based cross-linker and boronic acids in functional monomers, which selectively form a complex with a diol structure for selective removal of lactones from a coffee beverage. We synthesized a boronic acid monomer, 1-allylpyridinium-3-boronic acid, which has lower pKa and stronger binding strength to saccharides than commonly used boronic acids. Then, we prepared the MIPs with the monomer and succeeded in selective adsorption for a type of lactones, quinic acid gamma-lactone (QAGL). Furthermore, the high hydrophilicity of PEG and the molecular imprinting effect prevented an un-specific adsorption of other components in coffee. Finally, we achieved in removal of QAGL in coffee with high yield and at high speed by using the MIP-based microsphere as a separation medium in solid-phase extraction. This study provides a simple method for better-tasting freshly brewed coffee.

本文言語英語
ページ(範囲)226-232
ページ数7
ジャーナルACS Applied Polymer Materials
3
1
DOI
出版ステータス出版済み - 1月 8 2021
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • ポリマーおよびプラスチック
  • プロセス化学およびプロセス工学
  • 有機化学

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