Poly(ethylene glycol)-modified gold nanorods as a photothermal nanodevice for hyperthermia

Takuro Niidome, Yasuyuki Akiyama, Masato Yamagata, Takahito Kawano, Takeshi Mori, Yasuro Niidome, Yoshiki Katayama

研究成果: ジャーナルへの寄稿記事

73 引用 (Scopus)

抄録

Gold nanorods, which have a strong surface plasmon band at the near-infrared region, absorb light energy which is then converted to heat. Since near-infrared light can penetrate deeply into tissue, gold nanorods are expected to be useful as photosensitizers for photothermal therapy. In this study, the length of the poly(ethylene glycol) (PEG) chain was optimized in order to stabilize the gold nanorods in the blood circulation after intravenous injection. PEG5000- and PEG10000-modified gold nanorods showed higher stability in the blood circulation compared with PEG 2000- and PEG20000-modified gold nanorods. As a demonstration of photothermal tissue damage, PEG5000-modified gold nanorods were injected into the muscle in the hind limbs of a mouse, and then irradiated with near-infrared pulsed laser light. Significant tissue damage was observed only in the presence of gold nanorods and laser irradiation. We next injected the gold nanorods directly into subcutaneous tumors in mice, and then irradiated the tumor with near-infrared pulsed laser light. Significant suppression of tumor growth was observed. In the case of the intravenous injection of gold nanorods, the suppression of tumor growth was weaker than for the case of direct injection, indicating that the targeted delivery of gold nanorods to the tumor tissue is an important key to improve the therapeutic effect.

元の言語英語
ページ(範囲)1203-1215
ページ数13
ジャーナルJournal of Biomaterials Science, Polymer Edition
20
発行部数9
DOI
出版物ステータス出版済み - 5 1 2009

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Nanotubes
Ethylene Glycol
Nanorods
Gold
Polyethylene glycols
Fever
Tumors
Tissue
Light
Lasers
Infrared lasers
Blood Circulation
Hemodynamics
Neoplasms
Pulsed lasers
Intravenous Injections
Infrared radiation
Photosensitizing Agents
Photosensitizers
Direct injection

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

これを引用

Poly(ethylene glycol)-modified gold nanorods as a photothermal nanodevice for hyperthermia. / Niidome, Takuro; Akiyama, Yasuyuki; Yamagata, Masato; Kawano, Takahito; Mori, Takeshi; Niidome, Yasuro; Katayama, Yoshiki.

:: Journal of Biomaterials Science, Polymer Edition, 巻 20, 番号 9, 01.05.2009, p. 1203-1215.

研究成果: ジャーナルへの寄稿記事

Niidome, Takuro ; Akiyama, Yasuyuki ; Yamagata, Masato ; Kawano, Takahito ; Mori, Takeshi ; Niidome, Yasuro ; Katayama, Yoshiki. / Poly(ethylene glycol)-modified gold nanorods as a photothermal nanodevice for hyperthermia. :: Journal of Biomaterials Science, Polymer Edition. 2009 ; 巻 20, 番号 9. pp. 1203-1215.
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