In the β sheet structure of the peptide, the distance among the β-strands are 5 Å. This distance corresponds with distance among the monomer units of diacetylene and diene. Therefore the β-sheet will be able to be cross-linked by introducing these monomer units into the diacetylene and diene into peptide that formed β-sheet by using this. In this work, we synthesized peptide 1-4. Peptide 1 and 2 were design to form anti-parallel β-sheet alone. On the other hand, peptide 3 and 4 were design to form parallel β-sheet by mixing them. Polymerization of 1 and 2 was conducted by UV irradiation. After the polymerization, UV-vis spectra of 1 and 2 in dichloroacetic acid had an absorbance at 573 nm that originates in poly diacetylene. The result of FT-IR measurement of them showed disappearance of a peak at 2250 cm-1 that originates in diacetylene. Amide I region suggested that the peptides formed anti-parallel β-sheet and random coil. Therefore, it seemed that polymerization occurred in the β-sheet formed part.
|ホスト出版物のタイトル||54th SPSJ Annual Meeting 2005 - Polymer Preprints, Japan|
|出版ステータス||出版済み - 2005|
|イベント||54th SPSJ Annual Meeting 2005 - Yokohama, 日本|
継続期間: 5月 25 2005 → 5月 27 2005
|その他||54th SPSJ Annual Meeting 2005|
|Period||5/25/05 → 5/27/05|
!!!All Science Journal Classification (ASJC) codes