Polymorphism analysis of the upstream region of the human N-methyl-D-aspartate receptor subunit NR1 gene (GRIN1): Implications for schizophrenia

Ayako Tani, Rumiko Kikuta, Kanako Itoh, Akiko Joo, Hiroki Shibata, Hideaki Ninomiya, Nobutada Tashiro, Yasuyuki Fukumaki

研究成果: ジャーナルへの寄稿記事

19 引用 (Scopus)

抄録

Dysfunction of the gene for the NR1 subunit of the N-methyl-D-aspartate (NMDA) receptor (GRIN1) has been implicated in the pathogenesis of schizophrenia. In support of this hypothesis are behavioral abnormalities reminiscent of schizophrenia in mice with an attenuated expression of the NR1 subunit receptor and the reduced level of NR1 mRNA in postmortem brains of patients with schizophrenia. We screened single nucleotide polymorphisms (SNPs) in the upstream region between +51 and -941 from the translation initiation codon of GRIN1 and identified 17 SNPs, 10 of which were located within the region containing the Sp1 motif and the GSG motifs. As genotyping of 191-196 Japanese patients with schizophrenia and 202-216 controls revealed no significant association between schizophrenia and the SNPs in the upstream region of GRIN1, these SNPs apparently do not play a critical role in the pathogenesis of schizophrenia in the Japanese population.

元の言語英語
ページ(範囲)83-86
ページ数4
ジャーナルSchizophrenia research
58
発行部数1
DOI
出版物ステータス出版済み - 11 1 2002

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N-Methyl-D-Aspartate Receptors
Schizophrenia
Single Nucleotide Polymorphism
Genes
Initiator Codon
Messenger RNA
Brain
Population

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health
  • Biological Psychiatry

これを引用

Polymorphism analysis of the upstream region of the human N-methyl-D-aspartate receptor subunit NR1 gene (GRIN1) : Implications for schizophrenia. / Tani, Ayako; Kikuta, Rumiko; Itoh, Kanako; Joo, Akiko; Shibata, Hiroki; Ninomiya, Hideaki; Tashiro, Nobutada; Fukumaki, Yasuyuki.

:: Schizophrenia research, 巻 58, 番号 1, 01.11.2002, p. 83-86.

研究成果: ジャーナルへの寄稿記事

Tani, Ayako ; Kikuta, Rumiko ; Itoh, Kanako ; Joo, Akiko ; Shibata, Hiroki ; Ninomiya, Hideaki ; Tashiro, Nobutada ; Fukumaki, Yasuyuki. / Polymorphism analysis of the upstream region of the human N-methyl-D-aspartate receptor subunit NR1 gene (GRIN1) : Implications for schizophrenia. :: Schizophrenia research. 2002 ; 巻 58, 番号 1. pp. 83-86.
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abstract = "Dysfunction of the gene for the NR1 subunit of the N-methyl-D-aspartate (NMDA) receptor (GRIN1) has been implicated in the pathogenesis of schizophrenia. In support of this hypothesis are behavioral abnormalities reminiscent of schizophrenia in mice with an attenuated expression of the NR1 subunit receptor and the reduced level of NR1 mRNA in postmortem brains of patients with schizophrenia. We screened single nucleotide polymorphisms (SNPs) in the upstream region between +51 and -941 from the translation initiation codon of GRIN1 and identified 17 SNPs, 10 of which were located within the region containing the Sp1 motif and the GSG motifs. As genotyping of 191-196 Japanese patients with schizophrenia and 202-216 controls revealed no significant association between schizophrenia and the SNPs in the upstream region of GRIN1, these SNPs apparently do not play a critical role in the pathogenesis of schizophrenia in the Japanese population.",
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AU - Ninomiya, Hideaki

AU - Tashiro, Nobutada

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