Polymorphisms of cytochrome P450 1A1, glutathione S-transferase class mu, and tumour protein p53 genes and the risk of developing gallbladder cancer in Japanese

Yasuo Tsuchiya, Chikako Kiyohara, Toyoji Sato, Kazutoshi Nakamura, Akira Kimura, Masaharu Yamamoto

研究成果: ジャーナルへの寄稿学術誌査読

22 被引用数 (Scopus)

抄録

Objectives: To examine the relationship between genetic polymorphisms of cytochrome P450 1A1 (CYP1A1), glutathione S-transferase class mu (GSTM1), and tumour protein p53 (TP53) genes, and gallbladder cancer (GBC) risk, a case-control study was conducted. Design and methods: Genotypes of CYP1A1 T3801C, CYP1A1 Ile462Val, GSTM1, and TP53 Arg72Pro were determined in 54 cases of GBC and 178 controls. Results: The age-adjusted odds ratios (ORs) for the Ile/Val genotype of CYP1A1 Ile462Val polymorphism in women and the Arg/Pro genotype of TP53 Arg72Pro polymorphism in men were observed to be 2.70 (95% CI: 1.14-6.40) and 4.32 (95% CI: 1.08-17.2), respectively. No significant differences in the genotypic frequencies of CYP1A1 T3801C and GSTM1 polymorphisms were observed between controls and cases in both men and women. Conclusion: These results suggest that the Val allele of CYP1A1 Ile462Val polymorphism and the Pro allele of TP53 Arg72Pro polymorphism contribute to an increased risk of GBC among Japanese women and men, respectively.

本文言語英語
ページ(範囲)881-886
ページ数6
ジャーナルClinical Biochemistry
40
12
DOI
出版ステータス出版済み - 8月 2007

!!!All Science Journal Classification (ASJC) codes

  • 臨床生化学

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