Polyps with Different Grades of Dysplasia and their Distribution in the Colorectum

Manabu Yamamoto, Hiroyuki Mine, Hiroki Kusumoto, Yoshihiko Maehara, Keizo Sugimachi

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Background/Aims: To determine the role of adenomatous polyps in the development of colorectal cancers, we examined the relationship between the distribution and polyps with different grades of dysplasia (low, high), or/and cancers in the colorectum. Methodology: The distribution of 527 polyps with low-grade dysplasia was compared with that of 121 polyps with high-grade dysplasia, and 10 colorectal cancer lesions with adenomatous polyps in 361 patients who underwent total colonoscopy. Results: The distribution rate of polyps at the distal colon and rectum into polyps with high-grade dysplasia significantly increased in comparison to that into polyps with low-grade dysplasia, respectively (p < 0.002). The percentage of polyps with high-grade dysplasia measuring > 1cm significantly increased in comparison to that with low-grade dysplasia measuring > 1cm (p < 0.00001). In patients with both adenomatous polyps and colorectal cancers, the polyps with high-grade dysplasia at the distal sites of cancerous lesions increased significantly more than at the proximal sites of cancerous lesions (p < 0.05). Polyps with high-grade dysplasia have malignant potentials to intermediate between polyps with low-grade dysplasia and colorectal cancers in our study. Conclusions: The different distributions of different grades thus suggested that polyps with different grades of dysplasia at various colorectal sites were found to have different malignant potentials for cancer development.

元の言語英語
ページ(範囲)121-123
ページ数3
ジャーナルHepato-gastroenterology
51
発行部数55
出版物ステータス出版済み - 1 2004

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

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    Yamamoto, M., Mine, H., Kusumoto, H., Maehara, Y., & Sugimachi, K. (2004). Polyps with Different Grades of Dysplasia and their Distribution in the Colorectum. Hepato-gastroenterology, 51(55), 121-123.