Population genetics of tumor suppressor genes

Yoh Iwasa, Franziska Michor, Natalia L. Komarova, Martin A. Nowak

研究成果: Contribution to journalArticle査読

45 被引用数 (Scopus)

抄録

Cancer emerges when a single cell receives multiple mutations. For example, the inactivation of both alleles of a tumor suppressor gene (TSG) can imply a net reproductive advantage of the cell and might lead to clonal expansion. In this paper, we calculate the probability as a function of time that a population of cells has generated at least one cell with two inactivated alleles of a TSG. Different kinetic laws hold for small and large populations. The inactivation of the first allele can either be neutral or lead to a selective advantage or disadvantage. The inactivation of the first and of the second allele can occur at equal or different rates. Our calculations provide insights into basic aspects of population genetics determining cancer initiation and progression.

本文言語英語
ページ(範囲)15-23
ページ数9
ジャーナルJournal of Theoretical Biology
233
1
DOI
出版ステータス出版済み - 3 7 2005

All Science Journal Classification (ASJC) codes

  • 統計学および確率
  • モデリングとシミュレーション
  • 生化学、遺伝学、分子生物学(全般)
  • 免疫学および微生物学(全般)
  • 農業および生物科学(全般)
  • 応用数学

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