Pore collapse during the fabrication process of rubber-like polymer scaffolds

Raúl Brígido Diego, José Luis Gómez Ribelles, Manuel Salmerón Sánchez

研究成果: Contribution to journalArticle査読

9 被引用数 (Scopus)

抄録

Rubbery polymer scaffolds for tissue engineering were produced using templates of the pore structure. The last step in the fabrication process consists of dissolving the template using a solvent that, at the same time, swells the scaffolding matrix that was a polymer network. Sometimes the polymer matrix is stretched so strongly that when the solvent is eliminated, i.e., the network is dried, it shrinks and is not able to recover its original shape and, consequently, the porous structure collapses. In this work we prepared, using the same fabrication process (the same template and the same solvent), a series of polymer scaffolds that results in collapsed or noncollapsed porous structures, depending on the polymer network composition. Weexplain the collapse process as a consequence of the huge volume increase in the swelling process during the template extraction due to the large distance between crosslinking points in the scaffolding matrix. By systematically increasing the crosslinking density the porous structure remains after network drying and the final interconnected pores were observed. It is shown that this problem does not take place when the scaffolding matrix consists of aglassy polymer network.

本文言語英語
ページ(範囲)1475-1481
ページ数7
ジャーナルJournal of Applied Polymer Science
104
3
DOI
出版ステータス出版済み - 5 5 2007
外部発表はい

All Science Journal Classification (ASJC) codes

  • 化学 (全般)
  • 表面、皮膜および薄膜
  • ポリマーおよびプラスチック
  • 材料化学

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