Portal vein thrombosis after hepatectomy

Shohei Yoshiya, Ken Shirabe, Hidekazu Nakagawara, Yuji Soejima, Tomoharu Yoshizumi, Toru Ikegami, Yo Ichi Yamashita, Norifumi Harimoto, Akihiro Nishie, Takeharu Yamanaka, Yoshihiko Maehara

研究成果: ジャーナルへの寄稿記事

19 引用 (Scopus)

抄録

Background: Although various complications after hepatectomy have been reported, there have been no large studies on postoperative portal vein thrombosis (PVT) as a complication. This study evaluated the incidence, risk factors, and clinical outcomes of PVT after hepatectomy. Methods: The preoperative and postoperative clinical characteristics of patients who underwent hepatectomy were retrospectively analyzed. Results: A total of 208 patients were reviewed. The incidence of PVT after hepatectomy was 9.1 % (n = 19), including main portal vein (MPV) thrombosis (n = 7) and peripheral portal vein (PPV) thrombosis (n = 12). Patients with MPV thrombosis had a significantly higher incidence of right hepatectomy (p < 0.001), larger resection volume (p = 0.003), and longer operation time (p = 0.021) than patients without PVT (n = 189). Multivariate analysis identified right hepatectomy as a significant independent risk factor for MPV thrombosis (odds ratio 108.9; p < 0.001). Patients with PPV thrombosis had a significantly longer duration of Pringle maneuver than patients without PVT (p = 0.002). Among patients who underwent right hepatectomy, those with PVT (n = 6) had a significantly lower early liver regeneration rate than those without PVT (n = 13; p = 0.040), and those with PVT had deterioration of liver function on postoperative day 7. In all patients with MPV thrombosis who received anticoagulation therapy, PVT subsequently resolved. Conclusions: Postoperative PVT after hepatectomy is not rare. It is closely related to delayed recovery of liver function and delayed liver regeneration.

元の言語英語
ページ(範囲)1491-1497
ページ数7
ジャーナルWorld Journal of Surgery
38
発行部数6
DOI
出版物ステータス出版済み - 1 1 2014

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Hepatectomy
Portal Vein
Thrombosis
Liver Regeneration
Liver
Incidence
Recovery of Function

All Science Journal Classification (ASJC) codes

  • Surgery

これを引用

Portal vein thrombosis after hepatectomy. / Yoshiya, Shohei; Shirabe, Ken; Nakagawara, Hidekazu; Soejima, Yuji; Yoshizumi, Tomoharu; Ikegami, Toru; Yamashita, Yo Ichi; Harimoto, Norifumi; Nishie, Akihiro; Yamanaka, Takeharu; Maehara, Yoshihiko.

:: World Journal of Surgery, 巻 38, 番号 6, 01.01.2014, p. 1491-1497.

研究成果: ジャーナルへの寄稿記事

Yoshiya, S, Shirabe, K, Nakagawara, H, Soejima, Y, Yoshizumi, T, Ikegami, T, Yamashita, YI, Harimoto, N, Nishie, A, Yamanaka, T & Maehara, Y 2014, 'Portal vein thrombosis after hepatectomy', World Journal of Surgery, 巻. 38, 番号 6, pp. 1491-1497. https://doi.org/10.1007/s00268-013-2440-8
Yoshiya, Shohei ; Shirabe, Ken ; Nakagawara, Hidekazu ; Soejima, Yuji ; Yoshizumi, Tomoharu ; Ikegami, Toru ; Yamashita, Yo Ichi ; Harimoto, Norifumi ; Nishie, Akihiro ; Yamanaka, Takeharu ; Maehara, Yoshihiko. / Portal vein thrombosis after hepatectomy. :: World Journal of Surgery. 2014 ; 巻 38, 番号 6. pp. 1491-1497.
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abstract = "Background: Although various complications after hepatectomy have been reported, there have been no large studies on postoperative portal vein thrombosis (PVT) as a complication. This study evaluated the incidence, risk factors, and clinical outcomes of PVT after hepatectomy. Methods: The preoperative and postoperative clinical characteristics of patients who underwent hepatectomy were retrospectively analyzed. Results: A total of 208 patients were reviewed. The incidence of PVT after hepatectomy was 9.1 {\%} (n = 19), including main portal vein (MPV) thrombosis (n = 7) and peripheral portal vein (PPV) thrombosis (n = 12). Patients with MPV thrombosis had a significantly higher incidence of right hepatectomy (p < 0.001), larger resection volume (p = 0.003), and longer operation time (p = 0.021) than patients without PVT (n = 189). Multivariate analysis identified right hepatectomy as a significant independent risk factor for MPV thrombosis (odds ratio 108.9; p < 0.001). Patients with PPV thrombosis had a significantly longer duration of Pringle maneuver than patients without PVT (p = 0.002). Among patients who underwent right hepatectomy, those with PVT (n = 6) had a significantly lower early liver regeneration rate than those without PVT (n = 13; p = 0.040), and those with PVT had deterioration of liver function on postoperative day 7. In all patients with MPV thrombosis who received anticoagulation therapy, PVT subsequently resolved. Conclusions: Postoperative PVT after hepatectomy is not rare. It is closely related to delayed recovery of liver function and delayed liver regeneration.",
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T1 - Portal vein thrombosis after hepatectomy

AU - Yoshiya, Shohei

AU - Shirabe, Ken

AU - Nakagawara, Hidekazu

AU - Soejima, Yuji

AU - Yoshizumi, Tomoharu

AU - Ikegami, Toru

AU - Yamashita, Yo Ichi

AU - Harimoto, Norifumi

AU - Nishie, Akihiro

AU - Yamanaka, Takeharu

AU - Maehara, Yoshihiko

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Y1 - 2014/1/1

N2 - Background: Although various complications after hepatectomy have been reported, there have been no large studies on postoperative portal vein thrombosis (PVT) as a complication. This study evaluated the incidence, risk factors, and clinical outcomes of PVT after hepatectomy. Methods: The preoperative and postoperative clinical characteristics of patients who underwent hepatectomy were retrospectively analyzed. Results: A total of 208 patients were reviewed. The incidence of PVT after hepatectomy was 9.1 % (n = 19), including main portal vein (MPV) thrombosis (n = 7) and peripheral portal vein (PPV) thrombosis (n = 12). Patients with MPV thrombosis had a significantly higher incidence of right hepatectomy (p < 0.001), larger resection volume (p = 0.003), and longer operation time (p = 0.021) than patients without PVT (n = 189). Multivariate analysis identified right hepatectomy as a significant independent risk factor for MPV thrombosis (odds ratio 108.9; p < 0.001). Patients with PPV thrombosis had a significantly longer duration of Pringle maneuver than patients without PVT (p = 0.002). Among patients who underwent right hepatectomy, those with PVT (n = 6) had a significantly lower early liver regeneration rate than those without PVT (n = 13; p = 0.040), and those with PVT had deterioration of liver function on postoperative day 7. In all patients with MPV thrombosis who received anticoagulation therapy, PVT subsequently resolved. Conclusions: Postoperative PVT after hepatectomy is not rare. It is closely related to delayed recovery of liver function and delayed liver regeneration.

AB - Background: Although various complications after hepatectomy have been reported, there have been no large studies on postoperative portal vein thrombosis (PVT) as a complication. This study evaluated the incidence, risk factors, and clinical outcomes of PVT after hepatectomy. Methods: The preoperative and postoperative clinical characteristics of patients who underwent hepatectomy were retrospectively analyzed. Results: A total of 208 patients were reviewed. The incidence of PVT after hepatectomy was 9.1 % (n = 19), including main portal vein (MPV) thrombosis (n = 7) and peripheral portal vein (PPV) thrombosis (n = 12). Patients with MPV thrombosis had a significantly higher incidence of right hepatectomy (p < 0.001), larger resection volume (p = 0.003), and longer operation time (p = 0.021) than patients without PVT (n = 189). Multivariate analysis identified right hepatectomy as a significant independent risk factor for MPV thrombosis (odds ratio 108.9; p < 0.001). Patients with PPV thrombosis had a significantly longer duration of Pringle maneuver than patients without PVT (p = 0.002). Among patients who underwent right hepatectomy, those with PVT (n = 6) had a significantly lower early liver regeneration rate than those without PVT (n = 13; p = 0.040), and those with PVT had deterioration of liver function on postoperative day 7. In all patients with MPV thrombosis who received anticoagulation therapy, PVT subsequently resolved. Conclusions: Postoperative PVT after hepatectomy is not rare. It is closely related to delayed recovery of liver function and delayed liver regeneration.

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U2 - 10.1007/s00268-013-2440-8

DO - 10.1007/s00268-013-2440-8

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JO - World Journal of Surgery

JF - World Journal of Surgery

SN - 0364-2313

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