Positional information in neural map development: Lessons from the olfactory system

研究成果: ジャーナルへの寄稿評論記事

6 引用 (Scopus)

抄録

Positional information is fundamental in development. Although molecular gradients are thought to represent positional information in various systems, the molecular logic used to interpret these gradients remains controversial. In the nervous system, sensory maps are formed in the brain based on gradients of axon guidance molecules. However, it remains unclear how axons find their targets based on relative, not absolute, expression levels of axon guidance receptors. No model solely based on axon-target interactions explains this point. Recent studies in the olfactory system suggested that the neural map formation requires axon-axon interactions, which is known as axon sorting. This review discusses how axon-axon and axon-target interactions interpret molecular gradients and determine the axonal projection sites in neural map formation.

元の言語英語
ページ(範囲)358-365
ページ数8
ジャーナルDevelopment Growth and Differentiation
54
発行部数3
DOI
出版物ステータス出版済み - 4 1 2012

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Axons
Nervous System
Brain

All Science Journal Classification (ASJC) codes

  • Developmental Biology
  • Cell Biology

これを引用

Positional information in neural map development : Lessons from the olfactory system. / Imai, Takeshi.

:: Development Growth and Differentiation, 巻 54, 番号 3, 01.04.2012, p. 358-365.

研究成果: ジャーナルへの寄稿評論記事

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