Positional information in neural map development: Lessons from the olfactory system

研究成果: Contribution to journalReview article査読

7 被引用数 (Scopus)

抄録

Positional information is fundamental in development. Although molecular gradients are thought to represent positional information in various systems, the molecular logic used to interpret these gradients remains controversial. In the nervous system, sensory maps are formed in the brain based on gradients of axon guidance molecules. However, it remains unclear how axons find their targets based on relative, not absolute, expression levels of axon guidance receptors. No model solely based on axon-target interactions explains this point. Recent studies in the olfactory system suggested that the neural map formation requires axon-axon interactions, which is known as axon sorting. This review discusses how axon-axon and axon-target interactions interpret molecular gradients and determine the axonal projection sites in neural map formation.

本文言語英語
ページ(範囲)358-365
ページ数8
ジャーナルDevelopment Growth and Differentiation
54
3
DOI
出版ステータス出版済み - 4 2012
外部発表はい

All Science Journal Classification (ASJC) codes

  • Developmental Biology
  • Cell Biology

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