Positive selection of extrathymically developed T cells by self-antigens

Hisakata Yamada, Toshiharu Ninomiya, Asako Hashimoto, Koji Tamada, Hiroaki Takimoto, Kikuo Nomoto

研究成果: Contribution to journalArticle査読

32 被引用数 (Scopus)

抄録

Most T cells develop through the thymus, where they undergo positive and negative selection. Some peripheral T cells are known to develop in the absence of thymus, but there is insufficient information about their selection. To analyze the selection of extrathymically developed T cells, we reconstituted thymectomized male or female recipient mice with bone marrow cells of mice transgenic for male H-Y antigen-specific T cell receptor (TCR). It was revealed that the T cells bearing self-antigen-specific TCR were not deleted in thymectomized male recipients. More importantly, the absence of H- Y antigen-specific T cells in thymectomized female recipients suggests positive selection of extrathymically developed T cells by the self-antigen. The extrathymically developed T cells in male mice expressed interleukin (IL)-2 receptor β chain (IL-2Rβ) and intermediate levels of CD3 (CD3(int)) but were natural killer cell (NK) 1.1-. They rapidly produced interferon γ but not IL-4 after TCR cross-linking. Furthermore, a similar pattern of cytokine production was observed in CD3(int)IL-2RB+NK1.1- cells in normal mice which have been shown to develop extrathymically. These results suggest that extrathymically developed CD3(int)IL-2Rβ+NK1.1- cells in normal mice are also positively selected by self-antigens.

本文言語英語
ページ(範囲)779-784
ページ数6
ジャーナルJournal of Experimental Medicine
188
4
DOI
出版ステータス出版済み - 8 17 1998

All Science Journal Classification (ASJC) codes

  • 免疫アレルギー学
  • 免疫学

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