Positron labeled antioxidants

Synthesis and tissue biodistribution of 6-deoxy-6-[18F]fluoro-l-ascorbic acid

Fumihiko Yamamoto, Shigeki Sasaki, Minoru Maeda

研究成果: ジャーナルへの寄稿記事

23 引用 (Scopus)

抄録

A one-pot synthesis of 6-deoxy-6-[18F]fluoro-l-ascorbic acid (18F-DFA) has been developed via nucleophilic displacement of a cyclic sulfate with no-carrier-added [18F]fluoride ion. Isolated radiochemical yields of around 15% were obtained with radiochemical purity of over 99% after overall synthesis time of 90 min. Tissue distribution studies with 18F-DFA in rats showed high uptake of radioactivity in the adrenals, kidneys, liver and small intestine-organs known to have high concentrations of l-ascorbic acid. The slow and low uptake of radioactivity in the brain was observed between 10 and 120 min after i.v. injection. In vivo behavior of 18F-DFA in mice bearing 3-methylcholanthrene-induced fibrosarcoma demonstrated its ability to accumulate in the tumor.

元の言語英語
ページ(範囲)633-639
ページ数7
ジャーナルInternational Journal of Radiation Applications and Instrumentation. Part
43
発行部数5
DOI
出版物ステータス出版済み - 1 1 1992

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ascorbic acid
Ascorbic acid
Radioactivity
antioxidants
Positrons
radioactivity
Antioxidants
Ascorbic Acid
positrons
Bearings (structural)
Electrons
Tissue
intestines
Aptitude
Methylcholanthrene
Fibrosarcoma
kidneys
Tissue Distribution
synthesis
Fluorides

All Science Journal Classification (ASJC) codes

  • Engineering(all)

これを引用

Positron labeled antioxidants : Synthesis and tissue biodistribution of 6-deoxy-6-[18F]fluoro-l-ascorbic acid. / Yamamoto, Fumihiko; Sasaki, Shigeki; Maeda, Minoru.

:: International Journal of Radiation Applications and Instrumentation. Part, 巻 43, 番号 5, 01.01.1992, p. 633-639.

研究成果: ジャーナルへの寄稿記事

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