Possible association of atrophic gastritis and arterial stiffness in healthy middle-aged Japanese

Takehiro Torisu, Yutaka Takata, Toshihiro Ansai, Takayuki Matsumoto, Kazuo Sonoki, Inho Soh, Shuji Awano, Akihiro Yoshida, Tomoko Hamasaki, Shuntaro Kagiyama, Ikuo Nakamichi, Tomoko Ohsumi, Kuniaki Toyoshima, Tatsuji Nishihara, Mitsuo Iida, Tadamichi Takehara

研究成果: ジャーナルへの寄稿記事

10 引用 (Scopus)

抄録

Aim: Helicobacter pylori (HP) has been implicated as a risk factor for cardiovascular and atherosclerotic diseases. Arterial stiffness determined by pulse wave velocity (PWV) or the cardio-ankle vascular index (CAVI) has been shown to be higher in HP-positive subjects than in HP-negative subjects; however, this result has been observed only in young subjects. The aim of the study was to investigate the possible correlation between HP infection and PWV or CAVI in middle-aged subjects. Methods: We measured brachial-ankle PWV (baPWV), CAVI, metabolism markers, pepsinogens (PGs) and IgG antibody to HP in 343 individuals aged either 60 or 65 year old. Atrophic gastritis (AG) was diagnosed based on the values of PGs. Results: baPWV and CAVI were significantly higher in the AG-positive group than in the AG-negative group even after adjusting for possible confounding factors (baPWVc; 16.63±3.50 vs. 15.59± 3.47 p = 0.010, CAVIc; 8.59±1.20 vs. 8.27±1.19 p = 0.022). baPWV and CAVI values tended to be higher in the HP-positive group than in the HP-negative group. High-density lipoprotein (HDL) cholesterol level and the adiponectin level were lower in the AG-positive group than in the AG-negative group. Conclusion: There may be an association between atrophic gastritis and atherosclerosis in middleaged subjects.

元の言語英語
ページ(範囲)691-697
ページ数7
ジャーナルJournal of atherosclerosis and thrombosis
16
発行部数5
DOI
出版物ステータス出版済み - 1 1 2009

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Atrophic Gastritis
Vascular Stiffness
Pepsinogens
Ankle
Helicobacter pylori
Stiffness
Blood Vessels
Pulse Wave Analysis
Adiponectin
Metabolism
HDL Cholesterol
Arm
Immunoglobulin G
Antibodies
Helicobacter Infections
Atherosclerosis
Cardiovascular Diseases

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine
  • Biochemistry, medical

これを引用

Possible association of atrophic gastritis and arterial stiffness in healthy middle-aged Japanese. / Torisu, Takehiro; Takata, Yutaka; Ansai, Toshihiro; Matsumoto, Takayuki; Sonoki, Kazuo; Soh, Inho; Awano, Shuji; Yoshida, Akihiro; Hamasaki, Tomoko; Kagiyama, Shuntaro; Nakamichi, Ikuo; Ohsumi, Tomoko; Toyoshima, Kuniaki; Nishihara, Tatsuji; Iida, Mitsuo; Takehara, Tadamichi.

:: Journal of atherosclerosis and thrombosis, 巻 16, 番号 5, 01.01.2009, p. 691-697.

研究成果: ジャーナルへの寄稿記事

Torisu, T, Takata, Y, Ansai, T, Matsumoto, T, Sonoki, K, Soh, I, Awano, S, Yoshida, A, Hamasaki, T, Kagiyama, S, Nakamichi, I, Ohsumi, T, Toyoshima, K, Nishihara, T, Iida, M & Takehara, T 2009, 'Possible association of atrophic gastritis and arterial stiffness in healthy middle-aged Japanese', Journal of atherosclerosis and thrombosis, 巻. 16, 番号 5, pp. 691-697. https://doi.org/10.5551/jat.943
Torisu, Takehiro ; Takata, Yutaka ; Ansai, Toshihiro ; Matsumoto, Takayuki ; Sonoki, Kazuo ; Soh, Inho ; Awano, Shuji ; Yoshida, Akihiro ; Hamasaki, Tomoko ; Kagiyama, Shuntaro ; Nakamichi, Ikuo ; Ohsumi, Tomoko ; Toyoshima, Kuniaki ; Nishihara, Tatsuji ; Iida, Mitsuo ; Takehara, Tadamichi. / Possible association of atrophic gastritis and arterial stiffness in healthy middle-aged Japanese. :: Journal of atherosclerosis and thrombosis. 2009 ; 巻 16, 番号 5. pp. 691-697.
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title = "Possible association of atrophic gastritis and arterial stiffness in healthy middle-aged Japanese",
abstract = "Aim: Helicobacter pylori (HP) has been implicated as a risk factor for cardiovascular and atherosclerotic diseases. Arterial stiffness determined by pulse wave velocity (PWV) or the cardio-ankle vascular index (CAVI) has been shown to be higher in HP-positive subjects than in HP-negative subjects; however, this result has been observed only in young subjects. The aim of the study was to investigate the possible correlation between HP infection and PWV or CAVI in middle-aged subjects. Methods: We measured brachial-ankle PWV (baPWV), CAVI, metabolism markers, pepsinogens (PGs) and IgG antibody to HP in 343 individuals aged either 60 or 65 year old. Atrophic gastritis (AG) was diagnosed based on the values of PGs. Results: baPWV and CAVI were significantly higher in the AG-positive group than in the AG-negative group even after adjusting for possible confounding factors (baPWVc; 16.63±3.50 vs. 15.59± 3.47 p = 0.010, CAVIc; 8.59±1.20 vs. 8.27±1.19 p = 0.022). baPWV and CAVI values tended to be higher in the HP-positive group than in the HP-negative group. High-density lipoprotein (HDL) cholesterol level and the adiponectin level were lower in the AG-positive group than in the AG-negative group. Conclusion: There may be an association between atrophic gastritis and atherosclerosis in middleaged subjects.",
author = "Takehiro Torisu and Yutaka Takata and Toshihiro Ansai and Takayuki Matsumoto and Kazuo Sonoki and Inho Soh and Shuji Awano and Akihiro Yoshida and Tomoko Hamasaki and Shuntaro Kagiyama and Ikuo Nakamichi and Tomoko Ohsumi and Kuniaki Toyoshima and Tatsuji Nishihara and Mitsuo Iida and Tadamichi Takehara",
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TY - JOUR

T1 - Possible association of atrophic gastritis and arterial stiffness in healthy middle-aged Japanese

AU - Torisu, Takehiro

AU - Takata, Yutaka

AU - Ansai, Toshihiro

AU - Matsumoto, Takayuki

AU - Sonoki, Kazuo

AU - Soh, Inho

AU - Awano, Shuji

AU - Yoshida, Akihiro

AU - Hamasaki, Tomoko

AU - Kagiyama, Shuntaro

AU - Nakamichi, Ikuo

AU - Ohsumi, Tomoko

AU - Toyoshima, Kuniaki

AU - Nishihara, Tatsuji

AU - Iida, Mitsuo

AU - Takehara, Tadamichi

PY - 2009/1/1

Y1 - 2009/1/1

N2 - Aim: Helicobacter pylori (HP) has been implicated as a risk factor for cardiovascular and atherosclerotic diseases. Arterial stiffness determined by pulse wave velocity (PWV) or the cardio-ankle vascular index (CAVI) has been shown to be higher in HP-positive subjects than in HP-negative subjects; however, this result has been observed only in young subjects. The aim of the study was to investigate the possible correlation between HP infection and PWV or CAVI in middle-aged subjects. Methods: We measured brachial-ankle PWV (baPWV), CAVI, metabolism markers, pepsinogens (PGs) and IgG antibody to HP in 343 individuals aged either 60 or 65 year old. Atrophic gastritis (AG) was diagnosed based on the values of PGs. Results: baPWV and CAVI were significantly higher in the AG-positive group than in the AG-negative group even after adjusting for possible confounding factors (baPWVc; 16.63±3.50 vs. 15.59± 3.47 p = 0.010, CAVIc; 8.59±1.20 vs. 8.27±1.19 p = 0.022). baPWV and CAVI values tended to be higher in the HP-positive group than in the HP-negative group. High-density lipoprotein (HDL) cholesterol level and the adiponectin level were lower in the AG-positive group than in the AG-negative group. Conclusion: There may be an association between atrophic gastritis and atherosclerosis in middleaged subjects.

AB - Aim: Helicobacter pylori (HP) has been implicated as a risk factor for cardiovascular and atherosclerotic diseases. Arterial stiffness determined by pulse wave velocity (PWV) or the cardio-ankle vascular index (CAVI) has been shown to be higher in HP-positive subjects than in HP-negative subjects; however, this result has been observed only in young subjects. The aim of the study was to investigate the possible correlation between HP infection and PWV or CAVI in middle-aged subjects. Methods: We measured brachial-ankle PWV (baPWV), CAVI, metabolism markers, pepsinogens (PGs) and IgG antibody to HP in 343 individuals aged either 60 or 65 year old. Atrophic gastritis (AG) was diagnosed based on the values of PGs. Results: baPWV and CAVI were significantly higher in the AG-positive group than in the AG-negative group even after adjusting for possible confounding factors (baPWVc; 16.63±3.50 vs. 15.59± 3.47 p = 0.010, CAVIc; 8.59±1.20 vs. 8.27±1.19 p = 0.022). baPWV and CAVI values tended to be higher in the HP-positive group than in the HP-negative group. High-density lipoprotein (HDL) cholesterol level and the adiponectin level were lower in the AG-positive group than in the AG-negative group. Conclusion: There may be an association between atrophic gastritis and atherosclerosis in middleaged subjects.

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JO - Journal of Atherosclerosis and Thrombosis

JF - Journal of Atherosclerosis and Thrombosis

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