TY - JOUR
T1 - Possible heterogeneity of metabotropic glutamate receptors in duced in Xenopus oocytes by rat brain mRNA
AU - Tanabe, Shigeru
AU - Ito, Isao
AU - Sugiyama, Hiroyuki
PY - 1991/2
Y1 - 1991/2
N2 - Pharmacological properties of metabotropic glutamate receptors were studied in Xenopus oocytes injected with rat brain mRNA. trans-1-Amino-cyclopentyl-1,3-dicarboxylic acid (t-ACPD), a conformationally restricted analog of glutamate, induced oscillatory inward currents in mRNA-injected oocytes. These t-ACPD responses showed several characteristics identical to those of the other metabotropic responses including the metabotropic glutamate responses stimulated by quisqualate. d,l-2-Amino-3-phosphonopropionate (d,l-AP3) effectively suppressed the t-ACPD and ibotenate responses. However, quisqualate responses were not affected substantially by d,l-AP3. These findings suggest that the metabotropic glutamate receptors in the oocytes may be classified into at least two subtypes according to their pharmacological properties: one preferentially activated by quisqualate and insensitive to AP3, and the other activated by t-ACPD and ibotenate and antagonized by AP3.
AB - Pharmacological properties of metabotropic glutamate receptors were studied in Xenopus oocytes injected with rat brain mRNA. trans-1-Amino-cyclopentyl-1,3-dicarboxylic acid (t-ACPD), a conformationally restricted analog of glutamate, induced oscillatory inward currents in mRNA-injected oocytes. These t-ACPD responses showed several characteristics identical to those of the other metabotropic responses including the metabotropic glutamate responses stimulated by quisqualate. d,l-2-Amino-3-phosphonopropionate (d,l-AP3) effectively suppressed the t-ACPD and ibotenate responses. However, quisqualate responses were not affected substantially by d,l-AP3. These findings suggest that the metabotropic glutamate receptors in the oocytes may be classified into at least two subtypes according to their pharmacological properties: one preferentially activated by quisqualate and insensitive to AP3, and the other activated by t-ACPD and ibotenate and antagonized by AP3.
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U2 - 10.1016/0168-0102(91)90021-P
DO - 10.1016/0168-0102(91)90021-P
M3 - Article
C2 - 1851978
AN - SCOPUS:0025960124
VL - 10
SP - 71
EP - 77
JO - Neuroscience Research
JF - Neuroscience Research
SN - 0168-0102
IS - 1
ER -