TY - JOUR
T1 - Possible involvement of brain cytokines and 5-HT system in chronic fatigue syndrome
AU - Katafuchi, Toshihiko
N1 - Funding Information:
This work was performed through Special Coordination Funds for Promoting Science and Technology, and Grants-in-Aid for Scientific Research (17590207) to T.K. from the Ministry of Education, Culture, Sports, Science and Technology of the Japanese Government.
PY - 2006/4
Y1 - 2006/4
N2 - We have recently developed an animal model for fatigue induced by intraperitoneal (i.p.) injection of synthetic double-stranded RNAs, polyriboinosinic:polyribocytidylic acid (poly I:C) in rats. This animal model shows a decrease in daily amounts of spontaneous running wheel activity to about 60% of the preinjection level, and increase in interferon-α (IFN-α) mRNA in rat hypothalamic nuclei and cortex for more than a week. In addition, serotonin transporter (5-HTT), which is induced by IFN-α, also increased in the same regions. In vivo brain microdialysis demonstrated a decrease in 5-HT levels in the prefrontal cortex after poly I:C, which was blocked by a selective 5-HT reuptake inhibitor, fluoxetine. Furthermore, the poly I:C-induced suppression of the running wheel activity was attenuated by a 5-HT1A receptor agonist, but not by 5-HT2 and 5-HT3 receptor agonists. Possible involvement of IFN-α and 5-HT system in the mechanisms of the poly I:C-induced fatigue as well as CFS was discussed.
AB - We have recently developed an animal model for fatigue induced by intraperitoneal (i.p.) injection of synthetic double-stranded RNAs, polyriboinosinic:polyribocytidylic acid (poly I:C) in rats. This animal model shows a decrease in daily amounts of spontaneous running wheel activity to about 60% of the preinjection level, and increase in interferon-α (IFN-α) mRNA in rat hypothalamic nuclei and cortex for more than a week. In addition, serotonin transporter (5-HTT), which is induced by IFN-α, also increased in the same regions. In vivo brain microdialysis demonstrated a decrease in 5-HT levels in the prefrontal cortex after poly I:C, which was blocked by a selective 5-HT reuptake inhibitor, fluoxetine. Furthermore, the poly I:C-induced suppression of the running wheel activity was attenuated by a 5-HT1A receptor agonist, but not by 5-HT2 and 5-HT3 receptor agonists. Possible involvement of IFN-α and 5-HT system in the mechanisms of the poly I:C-induced fatigue as well as CFS was discussed.
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U2 - 10.1016/j.ics.2005.09.177
DO - 10.1016/j.ics.2005.09.177
M3 - Article
AN - SCOPUS:33646555103
VL - 1287
SP - 251
EP - 255
JO - International Congress Series
JF - International Congress Series
SN - 0531-5131
ER -