Possible involvement of cytokines, chemokines and chemokine receptors in the initiation and progression of chronic GVHD

J. N. Hayashida, S. Nakamura, T. Toyoshima, M. Moriyama, M. Sasaki, E. Kawamura, Y. Ohyama, W. Kumamaru, K. Shirasuna

研究成果: Contribution to journalArticle査読

15 被引用数 (Scopus)

抄録

Chronic GVHD (cGVHD) after allogeneic hematopoietic SCT (HSCT) is characterized by an infiltration of T cells into target organs including the oral mucosa and salivary glands. This study was designed to clarify the molecular mechanism of the local accumulation of pathogenic T cells in cGVHD. The expression of cytokines, chemokines and chemokine receptors in the buccal mucosa (BM), labial salivary glands (LSG) and PBMC from 16 patients with cGVHD after allogeneic HSCT was examined. The mRNA expression of T helper 1 (Th1) and Th2 cytokines, and several chemokines and chemokine receptors was significantly increased in the BM and LSG from cGVHD patients, in comparison with both those in the BM and LSG from controls, respectively, and also with those in the PBMC from cGVHD patients. Furthermore, the mRNA expression of Th2 cytokines, macrophage-derived chemokine and CC chemokine receptor 4 was closely associated with a strong T-cell infiltration in the BM and LSG from cGVHD patients. These results suggest that cGVHD might be initiated and/or maintained by Th1/Th0 cells and thereafter progresses in association with Th2 cell accumulation via the interaction of particular chemokine and chemokine receptors.

本文言語英語
ページ(範囲)115-123
ページ数9
ジャーナルBone Marrow Transplantation
48
1
DOI
出版ステータス出版済み - 1 2013

All Science Journal Classification (ASJC) codes

  • 血液学
  • 移植

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