Possible role of indoor environment and coal combustion emission in lung carcinogenesis in Fuyuan County, China

Y. Nakanishi, S. Chen, S. Inutsuka, Y. Ma, X. Jiang, N. Hara, N. Sera, H. Tokiwa

研究成果: Contribution to journalArticle査読

12 被引用数 (Scopus)

抄録

Fuyuan Country, in Yunnan Province, China has an extremely high lung cancer mortality both in males and non-smoking females. Out of 5768 deaths, 588 patients died of malignant diseases. Lung cancer was the number one cause of death among malignant diseases both in males and females. The rate of lung cancer death to the whole of malignant diseases was 56.2% for males and 55.0% for females. Indoor soot and combustion emission derived from smoky coal produced in northern Fuyuan exhibited high mutagenic activities against Salmonella typhimurium TA98 strain in Ames test. Resected lung tissues derived from the patients with lung cancer in Fuyuan contained significantly higher concentrations of benzo(a)pyrene than those in Japan, both in males and females (i.e., 608.7 ± 477.1 pg/dry weight for samples of the patients in Fuyuan, 180.1 ± 104.5 for Japanese non-smokers, and 207.5 ± 98.8 for Japanese heavy smokers, respectively). These results suggest that mutagenic chemicals contained in coal as well as indoor environment may have a great influence on lung carcinogenesis in Fuyuan, Yunnan Province, China.

本文言語英語
ページ(範囲)69-72
ページ数4
ジャーナルNeoplasma
44
1
出版ステータス出版済み - 1997

All Science Journal Classification (ASJC) codes

  • 癌研究

フィンガープリント

「Possible role of indoor environment and coal combustion emission in lung carcinogenesis in Fuyuan County, China」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル