Potentiation of 5-fluorouracil cytotoxicity by combining hyperthermia and dipyridamole in vitro

Y. Maehara, Y. Sakaguchi, T. Kusumoto, H. Kusumoto, K. Sugimachi

研究成果: ジャーナルへの寄稿記事

4 引用 (Scopus)

抄録

Evidence was obtained for the augmentation of cytotoxic effects of 5-fluorouracil (5-FU) when hyperthermia and dipyridamole (DP) were combined in vitro. Nontoxic levels of DP enhanced the combined cytotoxicity of 5-FU and heat against HeLa and B16 melanoma cells, and the 50% effective concentration of 5-FU decreased 7.3 fold for HeLa cells and 3.0 fold for B16 melanoma cells, when exposed to heat plus DP. This combined effect did not depend on intracellular increases in the concentrations of 5-FU. Thus hyperthermia together with DP seems to improve the sensitivity of tumor cells to 5-FU. As the sensitivity of colorectal cancer tissue to drugs is low, 5-FU plus hyperthermia and DP shows promise for the treatment of such patients.

元の言語英語
ページ(範囲)967-970
ページ数4
ジャーナルAnticancer research
9
発行部数4
出版物ステータス出版済み - 1 1 1989

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Dipyridamole
Fluorouracil
Fever
Experimental Melanomas
Hot Temperature
HeLa Cells
In Vitro Techniques
Colorectal Neoplasms
Pharmaceutical Preparations
Neoplasms

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

これを引用

Maehara, Y., Sakaguchi, Y., Kusumoto, T., Kusumoto, H., & Sugimachi, K. (1989). Potentiation of 5-fluorouracil cytotoxicity by combining hyperthermia and dipyridamole in vitro. Anticancer research, 9(4), 967-970.

Potentiation of 5-fluorouracil cytotoxicity by combining hyperthermia and dipyridamole in vitro. / Maehara, Y.; Sakaguchi, Y.; Kusumoto, T.; Kusumoto, H.; Sugimachi, K.

:: Anticancer research, 巻 9, 番号 4, 01.01.1989, p. 967-970.

研究成果: ジャーナルへの寄稿記事

Maehara, Y, Sakaguchi, Y, Kusumoto, T, Kusumoto, H & Sugimachi, K 1989, 'Potentiation of 5-fluorouracil cytotoxicity by combining hyperthermia and dipyridamole in vitro', Anticancer research, 巻. 9, 番号 4, pp. 967-970.
Maehara Y, Sakaguchi Y, Kusumoto T, Kusumoto H, Sugimachi K. Potentiation of 5-fluorouracil cytotoxicity by combining hyperthermia and dipyridamole in vitro. Anticancer research. 1989 1 1;9(4):967-970.
Maehara, Y. ; Sakaguchi, Y. ; Kusumoto, T. ; Kusumoto, H. ; Sugimachi, K. / Potentiation of 5-fluorouracil cytotoxicity by combining hyperthermia and dipyridamole in vitro. :: Anticancer research. 1989 ; 巻 9, 番号 4. pp. 967-970.
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