Practical synthesis of DOPA derivative for biosynthetic production of potent antitumor natural products, saframycins and ecteinascidin 743

Kohei Torikai, Takayoshi Saruwatari, Tatsuya Kitano, Takuya Sano, Atsuko Nakane, Hiroshi Noguchi, Kenji Watanabe

研究成果: ジャーナルへの寄稿記事

2 引用 (Scopus)

抜粋

A practical synthetic route of DOPA derivative 2, which should be useful for direct biosynthetic production of potent antitumor natural products, saframycins and ecteinascidin 743 was established. The developed strategy features i) easy-to-handle reactions without special care upon both dryness and inert atmopsphere, and ii) the facile HPLC-free purification of 2 via recrystallization enabling scalable synthesis of 2.

元の言語英語
ページ(範囲)686-689
ページ数4
ジャーナルLetters in Organic Chemistry
8
発行部数10
DOI
出版物ステータス出版済み - 12 2011

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Organic Chemistry

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