Pre-Target axon sorting establishes the neural map topography

Takeshi Imai, Takahiro Yamazaki, Reiko Kobayakawa, Ko Kobayakawa, Takaya Abe, Misao Suzuki, Hitoshi Sakano

研究成果: ジャーナルへの寄稿記事

136 引用 (Scopus)

抄録

Sensory information detected by the peripheral nervous system is represented as a topographic map in the brain. It has long been thought that the topography of the map is determined by graded positional cues that are expressed by the target. Here, we analyzed the pre-target axon sorting for olfactory map formation in mice. In olfactory sensory neurons, an axon guidance receptor, Neuropilin-1, and its repulsive ligand, Semaphorin-3A, are expressed in a complementary manner. We found that expression levels of Neuropilin-1 determined both pre-target sorting and projection sites of axons. Olfactory sensory neuron-specific knockout of Semaphorin-3A perturbed axon sorting and altered the olfactory map topography. Thus, pre-target axon sorting plays an important role in establishing the topographic order based on the relative levels of guidance molecules expressed by axons.

元の言語英語
ページ(範囲)585-590
ページ数6
ジャーナルScience
325
発行部数5940
DOI
出版物ステータス出版済み - 7 31 2009

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Axons
Semaphorin-3A
Neuropilin-1
Olfactory Receptor Neurons
Peripheral Nervous System
Cues
Ligands
Brain

All Science Journal Classification (ASJC) codes

  • General

これを引用

Imai, T., Yamazaki, T., Kobayakawa, R., Kobayakawa, K., Abe, T., Suzuki, M., & Sakano, H. (2009). Pre-Target axon sorting establishes the neural map topography. Science, 325(5940), 585-590. https://doi.org/10.1126/science.1173596

Pre-Target axon sorting establishes the neural map topography. / Imai, Takeshi; Yamazaki, Takahiro; Kobayakawa, Reiko; Kobayakawa, Ko; Abe, Takaya; Suzuki, Misao; Sakano, Hitoshi.

:: Science, 巻 325, 番号 5940, 31.07.2009, p. 585-590.

研究成果: ジャーナルへの寄稿記事

Imai, T, Yamazaki, T, Kobayakawa, R, Kobayakawa, K, Abe, T, Suzuki, M & Sakano, H 2009, 'Pre-Target axon sorting establishes the neural map topography', Science, 巻. 325, 番号 5940, pp. 585-590. https://doi.org/10.1126/science.1173596
Imai T, Yamazaki T, Kobayakawa R, Kobayakawa K, Abe T, Suzuki M その他. Pre-Target axon sorting establishes the neural map topography. Science. 2009 7 31;325(5940):585-590. https://doi.org/10.1126/science.1173596
Imai, Takeshi ; Yamazaki, Takahiro ; Kobayakawa, Reiko ; Kobayakawa, Ko ; Abe, Takaya ; Suzuki, Misao ; Sakano, Hitoshi. / Pre-Target axon sorting establishes the neural map topography. :: Science. 2009 ; 巻 325, 番号 5940. pp. 585-590.
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