抄録
Sensory information detected by the peripheral nervous system is represented as a topographic map in the brain. It has long been thought that the topography of the map is determined by graded positional cues that are expressed by the target. Here, we analyzed the pre-target axon sorting for olfactory map formation in mice. In olfactory sensory neurons, an axon guidance receptor, Neuropilin-1, and its repulsive ligand, Semaphorin-3A, are expressed in a complementary manner. We found that expression levels of Neuropilin-1 determined both pre-target sorting and projection sites of axons. Olfactory sensory neuron-specific knockout of Semaphorin-3A perturbed axon sorting and altered the olfactory map topography. Thus, pre-target axon sorting plays an important role in establishing the topographic order based on the relative levels of guidance molecules expressed by axons.
| 元の言語 | 英語 |
|---|---|
| ページ（範囲） | 585-590 |
| ページ数 | 6 |
| ジャーナル | Science |
| 巻 | 325 |
| 発行部数 | 5940 |
| DOI | |
| 出版物ステータス | 出版済み - 7 31 2009 |
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All Science Journal Classification (ASJC) codes
- General
これを引用
Pre-Target axon sorting establishes the neural map topography. / Imai, Takeshi; Yamazaki, Takahiro; Kobayakawa, Reiko; Kobayakawa, Ko; Abe, Takaya; Suzuki, Misao; Sakano, Hitoshi.
：: Science, 巻 325, 番号 5940, 31.07.2009, p. 585-590.研究成果: ジャーナルへの寄稿 › 記事
}
TY - JOUR
T1 - Pre-Target axon sorting establishes the neural map topography
AU - Imai, Takeshi
AU - Yamazaki, Takahiro
AU - Kobayakawa, Reiko
AU - Kobayakawa, Ko
AU - Abe, Takaya
AU - Suzuki, Misao
AU - Sakano, Hitoshi
PY - 2009/7/31
Y1 - 2009/7/31
N2 - Sensory information detected by the peripheral nervous system is represented as a topographic map in the brain. It has long been thought that the topography of the map is determined by graded positional cues that are expressed by the target. Here, we analyzed the pre-target axon sorting for olfactory map formation in mice. In olfactory sensory neurons, an axon guidance receptor, Neuropilin-1, and its repulsive ligand, Semaphorin-3A, are expressed in a complementary manner. We found that expression levels of Neuropilin-1 determined both pre-target sorting and projection sites of axons. Olfactory sensory neuron-specific knockout of Semaphorin-3A perturbed axon sorting and altered the olfactory map topography. Thus, pre-target axon sorting plays an important role in establishing the topographic order based on the relative levels of guidance molecules expressed by axons.
AB - Sensory information detected by the peripheral nervous system is represented as a topographic map in the brain. It has long been thought that the topography of the map is determined by graded positional cues that are expressed by the target. Here, we analyzed the pre-target axon sorting for olfactory map formation in mice. In olfactory sensory neurons, an axon guidance receptor, Neuropilin-1, and its repulsive ligand, Semaphorin-3A, are expressed in a complementary manner. We found that expression levels of Neuropilin-1 determined both pre-target sorting and projection sites of axons. Olfactory sensory neuron-specific knockout of Semaphorin-3A perturbed axon sorting and altered the olfactory map topography. Thus, pre-target axon sorting plays an important role in establishing the topographic order based on the relative levels of guidance molecules expressed by axons.
UR - http://www.scopus.com/inward/record.url?scp=68149107663&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=68149107663&partnerID=8YFLogxK
U2 - 10.1126/science.1173596
DO - 10.1126/science.1173596
M3 - Article
C2 - 19589963
AN - SCOPUS:68149107663
VL - 325
SP - 585
EP - 590
JO - Science
JF - Science
SN - 0036-8075
IS - 5940
ER -