Preceding immunosuppressive therapy with antithymocyte globulin and ciclosporin increases the incidence of graft rejection in children with aplastic anaemia who underwent allogeneic bone marrow transplantation from HLA-identical siblings

Ryoji Kobayashi, Hiromasa Yabe, Junichi Hara, Akira Morimoto, Masahiro Tsuchida, Hideo Mugishima, Akira Ohara, Ichiro Tsukimoto, Koji Kato, Hisato Kigasawa, Ken Tabuchi, Tatsutoshi Nakahata, Shoichi Ohga, Seiji Kojima

研究成果: ジャーナルへの寄稿学術誌査読

36 被引用数 (Scopus)

抄録

The incidence of graft rejection was determined in 66 children with acquired aplastic anaemia (AA) following bone marrow transplantation (BMT) from a related donor. Eleven of 65 evaluable patients experienced either early or late rejection. Multivariate analysis identified previous immunosuppressive therapy with antithymocyte-globulin (ATG) and ciclosporin (CsA) as a risk factor for graft rejection (relative risk: 16.6, P = 0.001). Patients who received ATG and CsA had a significantly lower probability of failure-free survival than those who did not (69.7 ± 6.2% vs. 87.9 ± 8.0%, P = 0.044). These results suggest that BMT should be instituted immediately in children with severe AA who have human leucocyte antigen-identical siblings.

本文言語英語
ページ(範囲)693-696
ページ数4
ジャーナルBritish Journal of Haematology
135
5
DOI
出版ステータス出版済み - 12月 2006

!!!All Science Journal Classification (ASJC) codes

  • 血液学

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