Prediction of cognitive function by arterial stiffness in the very elderly

Masayo Fukuhara, Kiyoshi Matsumura, Toshihiro Ansai, Yutaka Takata, Kazuo Sonoki, Sumio Akifusa, Masanori Wakisaka, Tomoko Hamasaki, Kiyoshi Fujisawa, Akihiro Yoshida, Koji Fujii, Mitsuo Iida, Tadamichi Takehara

研究成果: ジャーナルへの寄稿記事

36 引用 (Scopus)

抄録

Background: Cognitive function is impaired in elderly subjects, so the aim of the present study was to determine the role of arterial stiffness on cognitive function. Methods and Results: Cognitive function and arterial stiffness were assessed by the Mini-Mental State Examination (MMSE) and measurement of the brachial-ankle pulse wave velocity (PWV), respectively. The cross-sectional association of the MMSE score and PWV was studied in 203 subjects (87 men, 116 women), all of whom were 85 years old. Sex distribution, systolic and diastolic blood pressures did not differ between the normal (MMSE score ≥24, n=128) and impaired MMSE groups (MMSE score <24, n=75). In contrast, the PWV was significantly increased in the impaired MMSE group than in the normal MMSE group (25.0±0.8 vs 22.9±0.5 m/s, p<0.05). In multiple regression analysis, the PWV was also independently and significantly associated with the MMSE score. Conclusions: These results suggest that cognitive function could be predicted by arterial stiffness, as assessed by the PWV, in the very old. Preventing atherosclerosis may play an important role in preserving normal cognitive function until very old age.

元の言語英語
ページ(範囲)756-761
ページ数6
ジャーナルCirculation Journal
70
発行部数6
DOI
出版物ステータス出版済み - 6 5 2006

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Pulse Wave Analysis
Vascular Stiffness
Cognition
Blood Pressure
Sex Distribution
Ankle
Atherosclerosis
Arm
Regression Analysis

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

これを引用

Fukuhara, M., Matsumura, K., Ansai, T., Takata, Y., Sonoki, K., Akifusa, S., ... Takehara, T. (2006). Prediction of cognitive function by arterial stiffness in the very elderly. Circulation Journal, 70(6), 756-761. https://doi.org/10.1253/circj.70.756

Prediction of cognitive function by arterial stiffness in the very elderly. / Fukuhara, Masayo; Matsumura, Kiyoshi; Ansai, Toshihiro; Takata, Yutaka; Sonoki, Kazuo; Akifusa, Sumio; Wakisaka, Masanori; Hamasaki, Tomoko; Fujisawa, Kiyoshi; Yoshida, Akihiro; Fujii, Koji; Iida, Mitsuo; Takehara, Tadamichi.

:: Circulation Journal, 巻 70, 番号 6, 05.06.2006, p. 756-761.

研究成果: ジャーナルへの寄稿記事

Fukuhara, M, Matsumura, K, Ansai, T, Takata, Y, Sonoki, K, Akifusa, S, Wakisaka, M, Hamasaki, T, Fujisawa, K, Yoshida, A, Fujii, K, Iida, M & Takehara, T 2006, 'Prediction of cognitive function by arterial stiffness in the very elderly', Circulation Journal, 巻. 70, 番号 6, pp. 756-761. https://doi.org/10.1253/circj.70.756
Fukuhara M, Matsumura K, Ansai T, Takata Y, Sonoki K, Akifusa S その他. Prediction of cognitive function by arterial stiffness in the very elderly. Circulation Journal. 2006 6 5;70(6):756-761. https://doi.org/10.1253/circj.70.756
Fukuhara, Masayo ; Matsumura, Kiyoshi ; Ansai, Toshihiro ; Takata, Yutaka ; Sonoki, Kazuo ; Akifusa, Sumio ; Wakisaka, Masanori ; Hamasaki, Tomoko ; Fujisawa, Kiyoshi ; Yoshida, Akihiro ; Fujii, Koji ; Iida, Mitsuo ; Takehara, Tadamichi. / Prediction of cognitive function by arterial stiffness in the very elderly. :: Circulation Journal. 2006 ; 巻 70, 番号 6. pp. 756-761.
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abstract = "Background: Cognitive function is impaired in elderly subjects, so the aim of the present study was to determine the role of arterial stiffness on cognitive function. Methods and Results: Cognitive function and arterial stiffness were assessed by the Mini-Mental State Examination (MMSE) and measurement of the brachial-ankle pulse wave velocity (PWV), respectively. The cross-sectional association of the MMSE score and PWV was studied in 203 subjects (87 men, 116 women), all of whom were 85 years old. Sex distribution, systolic and diastolic blood pressures did not differ between the normal (MMSE score ≥24, n=128) and impaired MMSE groups (MMSE score <24, n=75). In contrast, the PWV was significantly increased in the impaired MMSE group than in the normal MMSE group (25.0±0.8 vs 22.9±0.5 m/s, p<0.05). In multiple regression analysis, the PWV was also independently and significantly associated with the MMSE score. Conclusions: These results suggest that cognitive function could be predicted by arterial stiffness, as assessed by the PWV, in the very old. Preventing atherosclerosis may play an important role in preserving normal cognitive function until very old age.",
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AU - Matsumura, Kiyoshi

AU - Ansai, Toshihiro

AU - Takata, Yutaka

AU - Sonoki, Kazuo

AU - Akifusa, Sumio

AU - Wakisaka, Masanori

AU - Hamasaki, Tomoko

AU - Fujisawa, Kiyoshi

AU - Yoshida, Akihiro

AU - Fujii, Koji

AU - Iida, Mitsuo

AU - Takehara, Tadamichi

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