Prediction of Key Factor Controlling G1/S Phase in the Mammalian Cell Cycle Using System Analysis

Yoshihiko Tashima, Hiroyuki Hamada, Masahiro Okamoto, Taizo Hanai

研究成果: ジャーナルへの寄稿記事

11 引用 (Scopus)

抄録

Control of the G1/S phase transition of the cell cycle contributes to the maintenance of homeostasis. It is well known that the disruption of the cell cycle is related to cell transformation and carcinogenesis. The G1/S phase transition involves a network of components that includes cyclins, cyclin-dependent kinases, and other proteins. Numerical simulation techniques and system analysis are expected to become powerful tools for investigating complex biological networks. To reach this goal, we designed a mathematical model of the G1/S phase transition. Using our model, we conducted a numerical simulation and comprehensive system analyses of this phase of the cell cycle. In this way, we were able to predict the key factors involved in the control of the G1/S transition.

元の言語英語
ページ(範囲)368-374
ページ数7
ジャーナルJournal of Bioscience and Bioengineering
106
発行部数4
DOI
出版物ステータス出版済み - 10 1 2008

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Phase Transition
G1 Phase
Systems Analysis
S Phase
Cell Cycle
Phase transitions
Systems analysis
Cells
Cyclins
Cyclin-Dependent Kinases
Computer simulation
Carcinogenesis
Homeostasis
Theoretical Models
Maintenance
Mathematical models
Proteins

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Applied Microbiology and Biotechnology
  • Bioengineering

これを引用

Prediction of Key Factor Controlling G1/S Phase in the Mammalian Cell Cycle Using System Analysis. / Tashima, Yoshihiko; Hamada, Hiroyuki; Okamoto, Masahiro; Hanai, Taizo.

:: Journal of Bioscience and Bioengineering, 巻 106, 番号 4, 01.10.2008, p. 368-374.

研究成果: ジャーナルへの寄稿記事

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