Predictive factors of biochemical recurrence after radical prostatectomy for high-risk prostate cancer

Yukiko Murata, Katsunori Tatsugami, Masahiro Yoshikawa, Masumitsu Hamaguchi, Shigetomo Yamada, Yusuke Hayakawa, Kouhei Ueda, Seiya Momosaki, Naotaka Sakamoto

研究成果: ジャーナルへの寄稿記事

3 引用 (Scopus)

抄録

Objective: To identify risk factors of biochemical recurrence after radical prostatectomy in high-risk patients. Methods: A total of 191 high-risk prostate cancer patients according to the D'Amico classification treated with radical prostatectomy at a single institution between April 2000 and December 2013 were enrolled. The pathological evaluation including intraductal carcinoma of prostate was reassessed, and the clinical and pathological risk factors of biochemical recurrence were analyzed. Results: The median follow up after radical prostatectomy was 49 months. The 5-year biochemical recurrence-free survival rate after radical prostatectomy in high-risk prostate cancer patients was 41.6%. Initial prostate-specific antigen, pathological Gleason score, seminal vesicle invasion, extraprostatic extension and intraductal carcinoma of the prostate were significantly associated with biochemical recurrence-free survival. The 5-year biochemical recurrence-free survival rates in patients with zero, one, two and three of these risk factors were 92.9%, 70.7%, 38.3% and 28.8%, respectively. In patients with four or more factors, the biochemical recurrence-free survival rate was 6.1% after 18 months. Conclusions: In D'Amico high-risk patients treated with radical prostatectomy, risk factors for biochemical recurrence can be identified. Patients with fewer risk factors have longer biochemical recurrence-free survival, even among these high-risk cases.

元の言語英語
ページ(範囲)284-289
ページ数6
ジャーナルInternational Journal of Urology
25
発行部数3
DOI
出版物ステータス出版済み - 3 1 2018

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Prostatectomy
Prostatic Neoplasms
Recurrence
Carcinoma, Intraductal, Noninfiltrating
Survival Rate
Prostate
Survival
Neoplasm Grading
Seminal Vesicles
Prostate-Specific Antigen

All Science Journal Classification (ASJC) codes

  • Urology

これを引用

Predictive factors of biochemical recurrence after radical prostatectomy for high-risk prostate cancer. / Murata, Yukiko; Tatsugami, Katsunori; Yoshikawa, Masahiro; Hamaguchi, Masumitsu; Yamada, Shigetomo; Hayakawa, Yusuke; Ueda, Kouhei; Momosaki, Seiya; Sakamoto, Naotaka.

:: International Journal of Urology, 巻 25, 番号 3, 01.03.2018, p. 284-289.

研究成果: ジャーナルへの寄稿記事

Murata, Y, Tatsugami, K, Yoshikawa, M, Hamaguchi, M, Yamada, S, Hayakawa, Y, Ueda, K, Momosaki, S & Sakamoto, N 2018, 'Predictive factors of biochemical recurrence after radical prostatectomy for high-risk prostate cancer', International Journal of Urology, 巻. 25, 番号 3, pp. 284-289. https://doi.org/10.1111/iju.13514
Murata, Yukiko ; Tatsugami, Katsunori ; Yoshikawa, Masahiro ; Hamaguchi, Masumitsu ; Yamada, Shigetomo ; Hayakawa, Yusuke ; Ueda, Kouhei ; Momosaki, Seiya ; Sakamoto, Naotaka. / Predictive factors of biochemical recurrence after radical prostatectomy for high-risk prostate cancer. :: International Journal of Urology. 2018 ; 巻 25, 番号 3. pp. 284-289.
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abstract = "Objective: To identify risk factors of biochemical recurrence after radical prostatectomy in high-risk patients. Methods: A total of 191 high-risk prostate cancer patients according to the D'Amico classification treated with radical prostatectomy at a single institution between April 2000 and December 2013 were enrolled. The pathological evaluation including intraductal carcinoma of prostate was reassessed, and the clinical and pathological risk factors of biochemical recurrence were analyzed. Results: The median follow up after radical prostatectomy was 49 months. The 5-year biochemical recurrence-free survival rate after radical prostatectomy in high-risk prostate cancer patients was 41.6{\%}. Initial prostate-specific antigen, pathological Gleason score, seminal vesicle invasion, extraprostatic extension and intraductal carcinoma of the prostate were significantly associated with biochemical recurrence-free survival. The 5-year biochemical recurrence-free survival rates in patients with zero, one, two and three of these risk factors were 92.9{\%}, 70.7{\%}, 38.3{\%} and 28.8{\%}, respectively. In patients with four or more factors, the biochemical recurrence-free survival rate was 6.1{\%} after 18 months. Conclusions: In D'Amico high-risk patients treated with radical prostatectomy, risk factors for biochemical recurrence can be identified. Patients with fewer risk factors have longer biochemical recurrence-free survival, even among these high-risk cases.",
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AU - Yamada, Shigetomo

AU - Hayakawa, Yusuke

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