Predictive Value of Ki-67 and Argyrophilic Nucleolar Organizer Region Staining for Lymph Node Metastasis in Gastric Cancer

Yoshihiro Kakeji, Daisuke Korenaga, Shunichi Tsujitani, Musarti Haraguchi, Yoshihiko Machara, Keizo Sugimachi

研究成果: ジャーナルへの寄稿学術誌査読

103 被引用数 (Scopus)

抄録

Proliferative activities in 91 primary gastric carcinomas and 36 corresponding metastatic perigastric lymph nodes were investigated using Ki-67 labeling percentage and an argyrophilic nucleolar organizer region (AgNOR) count. Tumors with a high proliferate activity often metastasized to lymph nodes, and the proliferate activities of the primary lesion and the perigastric lymph node metastaseswere similar. A signif icant correlation was recognized between the Ki-67 labeling percentage and the AgNOR count (r = 0.744; P < 0.001). The Ki-67 labeling percentage and AgNOR count proved to be useful predictors of nodal metastasis regardless of tumor size, depth of invasion, and histological type. Even when tumors are smaller (<7 cm) or the stage of the disease is early (pTl, 2), the formation of metastasis increased with an increased Ki-67 labeling percentage or AgNOR count. The combination analysis of depth of invasion with Ki-67 labeling percentage or AgNOR count gives a more precise prediction of nodal metastasis, compared with histological analysis alone.

本文言語英語
ページ(範囲)3503-3506
ページ数4
ジャーナルCancer Research
51
13
出版ステータス出版済み - 7月 1 1991
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 腫瘍学
  • 癌研究

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