Predictive value of preoperative carcinoembryonic antigen levels for the prognosis of patients with well-differentiated gastric cancer: A mutivariate analysis

Yoshihiko Maehar, Tetsuya Kusumoto, Ikuo Takahashi, Yoshihiro Kakeji, Hideo Baba, Kouhei Akazawa, Keizo Sugimachi

研究成果: Contribution to journalArticle査読

25 被引用数 (Scopus)

抄録

Serum carcinoembryonic antigen (CEA) levels were determined preoperatively in 221 patients with well-differentiated gastric cancer. The mean preoperative serum CEA level was 15.9 ± 88.5 ng/ml (1.0-1,133.0 ng/ml) for all patients, and the incidence of an elevated CEA (>5 ng/ml) was 11.8% (26/221). The CEA-positive patients had larger tumors, a more prominent serosal invasion, more frequent lymphatic and vascular involvement, less expansive tumor growth and higher rates of lymph node and hepatic metastases than did the CEA-negative patients. Thus, the CEA-positive patients had a more advanced stage of disease, and 61.5% underwent noncurative resection (vs. 11.3% in CEA-negative patients). The survival rate of the CEA-positive patients was lower than that of the CEA-negative ones (p < 0.01). As the multivariate analysis revealed the preoperative CEA level to be an independent prognostic factor for survival, an assay for this antigen prior to surgery is to be recommended.

本文言語英語
ページ(範囲)234-237
ページ数4
ジャーナルOncology (Switzerland)
51
3
DOI
出版ステータス出版済み - 1994

All Science Journal Classification (ASJC) codes

  • 腫瘍学
  • 癌研究

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