Predictors for microinvasion of small hepatocellular carcinoma ≤2 cm

Yo Ichi Yamashita, Eiji Tsuijita, kazuki takeishi, Megumu Fujiwara, Shinsuke Kira, Masaki Mori, Shinichi Aishima, Akinobu Taketomi, Ken Shirabe, Terutoshi Ishida, Yoshihiko Maehara

研究成果: ジャーナルへの寄稿評論記事

66 引用 (Scopus)

抄録

Background. Hepatocellular carcinoma (HCC) ≤2 cm in diameter is considered to have a low potential for malignancy. Methods. A retrospective review was undertaken of 149 patients with primary solitary HCC ≤2 cm who underwent initial hepatic resection between 1994 and 2010. The independent predictors of the microinvasion (MI) such as portal venous, hepatic vein, or bile duct infiltration and/or intrahepatic metastasis were identified by multivariate analysis. Prognosis of patients with HCC ≤2 cm accompanied by MI was compared to that of patients with HCC ≤2 cm without MI. Results. Forty-three patients with HCC ≤2 cm had MI in patients (28.9%). Three independent predictors of the MI were revealed: invasive gross type (simple nodular type with extranodular growth or confluent multinodular type), des-c-carboxy prothrombin (DCP) >100 mAU/ml, and poorly differentiated. Disease-free survival rates of patients with HCC ≤2 cm with MI (3 year 44%) were significantly worse than those for HCC ≤2 cm without MI (3 year 72%). This disadvantage of disease-free survival rate of patients with HCC ≤2 cm with MI could be dissolved by hepatic resection with a wide tumor margin of C5 mm (P = 0.04). Conclusions. Even in cases of HCC ≤2 cm, patients who are suspected of having invasive gross type tumors in preoperative imaging diagnosis or who have a high DCP level (>100 mAU/ml) are at risk for MI. Therefore, in such patients, hepatic resection with a wide tumor margin should be recommended.

元の言語英語
ページ(範囲)2027-2034
ページ数8
ジャーナルAnnals of Surgical Oncology
19
発行部数6
DOI
出版物ステータス出版済み - 6 1 2012

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Hepatocellular Carcinoma
Prothrombin
Disease-Free Survival
Liver
Neoplasms
Survival Rate
Common Hepatic Duct
Hepatic Veins
Bile Ducts
Multivariate Analysis
Neoplasm Metastasis
Growth

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oncology

これを引用

Predictors for microinvasion of small hepatocellular carcinoma ≤2 cm. / Yamashita, Yo Ichi; Tsuijita, Eiji; takeishi, kazuki; Fujiwara, Megumu; Kira, Shinsuke; Mori, Masaki; Aishima, Shinichi; Taketomi, Akinobu; Shirabe, Ken; Ishida, Terutoshi; Maehara, Yoshihiko.

:: Annals of Surgical Oncology, 巻 19, 番号 6, 01.06.2012, p. 2027-2034.

研究成果: ジャーナルへの寄稿評論記事

Yamashita, YI, Tsuijita, E, takeishi, K, Fujiwara, M, Kira, S, Mori, M, Aishima, S, Taketomi, A, Shirabe, K, Ishida, T & Maehara, Y 2012, 'Predictors for microinvasion of small hepatocellular carcinoma ≤2 cm', Annals of Surgical Oncology, 巻. 19, 番号 6, pp. 2027-2034. https://doi.org/10.1245/s10434-011-2195-0
Yamashita, Yo Ichi ; Tsuijita, Eiji ; takeishi, kazuki ; Fujiwara, Megumu ; Kira, Shinsuke ; Mori, Masaki ; Aishima, Shinichi ; Taketomi, Akinobu ; Shirabe, Ken ; Ishida, Terutoshi ; Maehara, Yoshihiko. / Predictors for microinvasion of small hepatocellular carcinoma ≤2 cm. :: Annals of Surgical Oncology. 2012 ; 巻 19, 番号 6. pp. 2027-2034.
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abstract = "Background. Hepatocellular carcinoma (HCC) ≤2 cm in diameter is considered to have a low potential for malignancy. Methods. A retrospective review was undertaken of 149 patients with primary solitary HCC ≤2 cm who underwent initial hepatic resection between 1994 and 2010. The independent predictors of the microinvasion (MI) such as portal venous, hepatic vein, or bile duct infiltration and/or intrahepatic metastasis were identified by multivariate analysis. Prognosis of patients with HCC ≤2 cm accompanied by MI was compared to that of patients with HCC ≤2 cm without MI. Results. Forty-three patients with HCC ≤2 cm had MI in patients (28.9{\%}). Three independent predictors of the MI were revealed: invasive gross type (simple nodular type with extranodular growth or confluent multinodular type), des-c-carboxy prothrombin (DCP) >100 mAU/ml, and poorly differentiated. Disease-free survival rates of patients with HCC ≤2 cm with MI (3 year 44{\%}) were significantly worse than those for HCC ≤2 cm without MI (3 year 72{\%}). This disadvantage of disease-free survival rate of patients with HCC ≤2 cm with MI could be dissolved by hepatic resection with a wide tumor margin of C5 mm (P = 0.04). Conclusions. Even in cases of HCC ≤2 cm, patients who are suspected of having invasive gross type tumors in preoperative imaging diagnosis or who have a high DCP level (>100 mAU/ml) are at risk for MI. Therefore, in such patients, hepatic resection with a wide tumor margin should be recommended.",
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T1 - Predictors for microinvasion of small hepatocellular carcinoma ≤2 cm

AU - Yamashita, Yo Ichi

AU - Tsuijita, Eiji

AU - takeishi, kazuki

AU - Fujiwara, Megumu

AU - Kira, Shinsuke

AU - Mori, Masaki

AU - Aishima, Shinichi

AU - Taketomi, Akinobu

AU - Shirabe, Ken

AU - Ishida, Terutoshi

AU - Maehara, Yoshihiko

PY - 2012/6/1

Y1 - 2012/6/1

N2 - Background. Hepatocellular carcinoma (HCC) ≤2 cm in diameter is considered to have a low potential for malignancy. Methods. A retrospective review was undertaken of 149 patients with primary solitary HCC ≤2 cm who underwent initial hepatic resection between 1994 and 2010. The independent predictors of the microinvasion (MI) such as portal venous, hepatic vein, or bile duct infiltration and/or intrahepatic metastasis were identified by multivariate analysis. Prognosis of patients with HCC ≤2 cm accompanied by MI was compared to that of patients with HCC ≤2 cm without MI. Results. Forty-three patients with HCC ≤2 cm had MI in patients (28.9%). Three independent predictors of the MI were revealed: invasive gross type (simple nodular type with extranodular growth or confluent multinodular type), des-c-carboxy prothrombin (DCP) >100 mAU/ml, and poorly differentiated. Disease-free survival rates of patients with HCC ≤2 cm with MI (3 year 44%) were significantly worse than those for HCC ≤2 cm without MI (3 year 72%). This disadvantage of disease-free survival rate of patients with HCC ≤2 cm with MI could be dissolved by hepatic resection with a wide tumor margin of C5 mm (P = 0.04). Conclusions. Even in cases of HCC ≤2 cm, patients who are suspected of having invasive gross type tumors in preoperative imaging diagnosis or who have a high DCP level (>100 mAU/ml) are at risk for MI. Therefore, in such patients, hepatic resection with a wide tumor margin should be recommended.

AB - Background. Hepatocellular carcinoma (HCC) ≤2 cm in diameter is considered to have a low potential for malignancy. Methods. A retrospective review was undertaken of 149 patients with primary solitary HCC ≤2 cm who underwent initial hepatic resection between 1994 and 2010. The independent predictors of the microinvasion (MI) such as portal venous, hepatic vein, or bile duct infiltration and/or intrahepatic metastasis were identified by multivariate analysis. Prognosis of patients with HCC ≤2 cm accompanied by MI was compared to that of patients with HCC ≤2 cm without MI. Results. Forty-three patients with HCC ≤2 cm had MI in patients (28.9%). Three independent predictors of the MI were revealed: invasive gross type (simple nodular type with extranodular growth or confluent multinodular type), des-c-carboxy prothrombin (DCP) >100 mAU/ml, and poorly differentiated. Disease-free survival rates of patients with HCC ≤2 cm with MI (3 year 44%) were significantly worse than those for HCC ≤2 cm without MI (3 year 72%). This disadvantage of disease-free survival rate of patients with HCC ≤2 cm with MI could be dissolved by hepatic resection with a wide tumor margin of C5 mm (P = 0.04). Conclusions. Even in cases of HCC ≤2 cm, patients who are suspected of having invasive gross type tumors in preoperative imaging diagnosis or who have a high DCP level (>100 mAU/ml) are at risk for MI. Therefore, in such patients, hepatic resection with a wide tumor margin should be recommended.

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JO - Annals of Surgical Oncology

JF - Annals of Surgical Oncology

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