Predictors of kidney tubular dysfunction induced by adefovir treatment for chronic hepatitis B

motohiro shimizu, Norihiro Furusyo, Hiroaki Ikezaki, Eiichi Ogawa, Takeo Hayashi, Takeshi Ihara, Yuji Harada, Kazuhiro Toyoda, Murata Masayuki, Jun Hayashi

研究成果: ジャーナルへの寄稿記事

13 引用 (Scopus)

抄録

AIM: To investigate the predictors of proximal kidney tubular dysfunction (PKTD) induced by adefovir dipivoxil (ADV) treatment for chronic hepatitis B. METHODS: Seventy-nine patients (age at the evaluation of PKTD: 56.9 ± 10.7 years) with chronic hepatitis B undergoing long-term oral antiviral nucleos(t)ide analogue treatment were consecutively recruited. PKTD was defined by the presence of at least two of the following five abnormalities: phosphate diabetes, nondiabetic glucosuria, metabolic acidosis, β2-microglobulinuria, or renal hypouricemia. The single-nucleotide polymorphisms (SNPs) in the SLC22A6 gene encoding human organic anion transporter 1 (hOAT1) and ABCC2 encoding multidrug resistance protein 2 (MRP2) were analyzed using the TaqMan Allelic Discrimination Demonstration Kit. RESULTS: Nine (30.0%) of the 30 ADV-treated patients were diagnosed with PKTD, while no patients without ADV developed PKTD (P < 0.001). Three patients with ADV were diagnosed with symptomatic osteomalacia. Among the patients who took ADV, those with PKTD were of higher age at initiation, had significantly longer treatment duration, and had a significantly lower body mass index than those without PKTD. The incidence of PKTD dramatically increased after 96 mo from the start of ADV administration. In contrast, the SNPs were not correlated with PKTD. Logistic regression analysis extracted older age at initiation (OR = 5.0, 95%CI: 1.1-23.4; P = 0.040) and longer treatment duration (OR = 3.2, 95%CI: 1.2-8.6; P = 0.020) as significant factors associated with PKTD. CONCLUSION: Our results suggest that the tubular function of the kidney of older patients undergoing long-term ADV treatment should be carefully evaluated.

元の言語英語
ページ(範囲)2116-2123
ページ数8
ジャーナルWorld Journal of Gastroenterology
21
発行部数7
DOI
出版物ステータス出版済み - 1 1 2015

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Chronic Hepatitis B
Kidney
Therapeutics
Single Nucleotide Polymorphism
adefovir
Familial Hypophosphatemia
Organic Anion Transporters
Osteomalacia
Acidosis
adefovir dipivoxil
Antiviral Agents
Body Mass Index
Logistic Models
Regression Analysis

All Science Journal Classification (ASJC) codes

  • Gastroenterology

これを引用

Predictors of kidney tubular dysfunction induced by adefovir treatment for chronic hepatitis B. / shimizu, motohiro; Furusyo, Norihiro; Ikezaki, Hiroaki; Ogawa, Eiichi; Hayashi, Takeo; Ihara, Takeshi; Harada, Yuji; Toyoda, Kazuhiro; Masayuki, Murata; Hayashi, Jun.

:: World Journal of Gastroenterology, 巻 21, 番号 7, 01.01.2015, p. 2116-2123.

研究成果: ジャーナルへの寄稿記事

shimizu, motohiro ; Furusyo, Norihiro ; Ikezaki, Hiroaki ; Ogawa, Eiichi ; Hayashi, Takeo ; Ihara, Takeshi ; Harada, Yuji ; Toyoda, Kazuhiro ; Masayuki, Murata ; Hayashi, Jun. / Predictors of kidney tubular dysfunction induced by adefovir treatment for chronic hepatitis B. :: World Journal of Gastroenterology. 2015 ; 巻 21, 番号 7. pp. 2116-2123.
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abstract = "AIM: To investigate the predictors of proximal kidney tubular dysfunction (PKTD) induced by adefovir dipivoxil (ADV) treatment for chronic hepatitis B. METHODS: Seventy-nine patients (age at the evaluation of PKTD: 56.9 ± 10.7 years) with chronic hepatitis B undergoing long-term oral antiviral nucleos(t)ide analogue treatment were consecutively recruited. PKTD was defined by the presence of at least two of the following five abnormalities: phosphate diabetes, nondiabetic glucosuria, metabolic acidosis, β2-microglobulinuria, or renal hypouricemia. The single-nucleotide polymorphisms (SNPs) in the SLC22A6 gene encoding human organic anion transporter 1 (hOAT1) and ABCC2 encoding multidrug resistance protein 2 (MRP2) were analyzed using the TaqMan Allelic Discrimination Demonstration Kit. RESULTS: Nine (30.0{\%}) of the 30 ADV-treated patients were diagnosed with PKTD, while no patients without ADV developed PKTD (P < 0.001). Three patients with ADV were diagnosed with symptomatic osteomalacia. Among the patients who took ADV, those with PKTD were of higher age at initiation, had significantly longer treatment duration, and had a significantly lower body mass index than those without PKTD. The incidence of PKTD dramatically increased after 96 mo from the start of ADV administration. In contrast, the SNPs were not correlated with PKTD. Logistic regression analysis extracted older age at initiation (OR = 5.0, 95{\%}CI: 1.1-23.4; P = 0.040) and longer treatment duration (OR = 3.2, 95{\%}CI: 1.2-8.6; P = 0.020) as significant factors associated with PKTD. CONCLUSION: Our results suggest that the tubular function of the kidney of older patients undergoing long-term ADV treatment should be carefully evaluated.",
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AU - shimizu, motohiro

AU - Furusyo, Norihiro

AU - Ikezaki, Hiroaki

AU - Ogawa, Eiichi

AU - Hayashi, Takeo

AU - Ihara, Takeshi

AU - Harada, Yuji

AU - Toyoda, Kazuhiro

AU - Masayuki, Murata

AU - Hayashi, Jun

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N2 - AIM: To investigate the predictors of proximal kidney tubular dysfunction (PKTD) induced by adefovir dipivoxil (ADV) treatment for chronic hepatitis B. METHODS: Seventy-nine patients (age at the evaluation of PKTD: 56.9 ± 10.7 years) with chronic hepatitis B undergoing long-term oral antiviral nucleos(t)ide analogue treatment were consecutively recruited. PKTD was defined by the presence of at least two of the following five abnormalities: phosphate diabetes, nondiabetic glucosuria, metabolic acidosis, β2-microglobulinuria, or renal hypouricemia. The single-nucleotide polymorphisms (SNPs) in the SLC22A6 gene encoding human organic anion transporter 1 (hOAT1) and ABCC2 encoding multidrug resistance protein 2 (MRP2) were analyzed using the TaqMan Allelic Discrimination Demonstration Kit. RESULTS: Nine (30.0%) of the 30 ADV-treated patients were diagnosed with PKTD, while no patients without ADV developed PKTD (P < 0.001). Three patients with ADV were diagnosed with symptomatic osteomalacia. Among the patients who took ADV, those with PKTD were of higher age at initiation, had significantly longer treatment duration, and had a significantly lower body mass index than those without PKTD. The incidence of PKTD dramatically increased after 96 mo from the start of ADV administration. In contrast, the SNPs were not correlated with PKTD. Logistic regression analysis extracted older age at initiation (OR = 5.0, 95%CI: 1.1-23.4; P = 0.040) and longer treatment duration (OR = 3.2, 95%CI: 1.2-8.6; P = 0.020) as significant factors associated with PKTD. CONCLUSION: Our results suggest that the tubular function of the kidney of older patients undergoing long-term ADV treatment should be carefully evaluated.

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