Preferential expression of OVOL1 in inner root sheath of hair, sebaceous gland, eccrine duct and their neoplasms in human skin

Chikage Mitoma, Takeshi Nakahara, Uchi Hiroshi, Takamichi Ito, yusuke inatomi, Takatoshi Ide, Shunichi Jinnai, Naomi Jinnai, Nahoko Zeze, Keiko Sakamoto, nanae kimura, Ayami Maeda, Yuki Kuma, Eriko Maehara, Midori Tsutsumi, Makiko Kido-Nakahara, Tomomitsu Hirota, Mayumi Tamari, Masutaka Furue

研究成果: ジャーナルへの寄稿記事

5 引用 (Scopus)

抄録

OVOL1 is an important transcription factor for epidermal keratinization, which suppresses proliferation and switches on the differentiation of keratinocytes. A recent genome-wide association study has revealed that OVOL1 is one of the genes associated with susceptibility to atopic dermatitis. Although it is known to be expressed in murine skin and hair follicles, no investigations have focused on its localization in human skin. In the present study, we thus immunolocalized the expression of OVOL1 in normal and diseased human skin. In normal human skin, OVOL1 was preferentially expressed in the suprabasal layer of the epidermis, inner root sheath of hair, mature sebocytes and the ductal portion of the eccrine glands. Compared to this, no remarkable change in the expression of OVOL1 was observed among inflammatory skin diseases. The expression of OVOL1 was evident in eccrine poroma and hidradenoma. Moreover, it was overexpressed in Bowen's disease and sebaceous adenoma, in sharp contrast to its downregulation in their more malignant counterparts, squamous cell carcinoma and sebaceous carcinoma. OVOL1 may play an important role in human skin morphogenesis and tumorigenesis.

元の言語英語
ページ(範囲)166-173
ページ数8
ジャーナルFukuoka igaku zasshi = Hukuoka acta medica
105
発行部数8
出版物ステータス出版済み - 8 1 2014

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Sebaceous Glands
Hair
Skin
Skin Diseases
Neoplasms
Poroma
Acrospiroma
Eccrine Glands
Bowen's Disease
Hair Follicle
Genome-Wide Association Study
Atopic Dermatitis
Morphogenesis
Keratinocytes
Epidermis
Adenoma
Squamous Cell Carcinoma
Carcinogenesis
Transcription Factors
Down-Regulation

All Science Journal Classification (ASJC) codes

  • Medicine(all)

これを引用

Preferential expression of OVOL1 in inner root sheath of hair, sebaceous gland, eccrine duct and their neoplasms in human skin. / Mitoma, Chikage; Nakahara, Takeshi; Hiroshi, Uchi; Ito, Takamichi; inatomi, yusuke; Ide, Takatoshi; Jinnai, Shunichi; Jinnai, Naomi; Zeze, Nahoko; Sakamoto, Keiko; kimura, nanae; Maeda, Ayami; Kuma, Yuki; Maehara, Eriko; Tsutsumi, Midori; Kido-Nakahara, Makiko; Hirota, Tomomitsu; Tamari, Mayumi; Furue, Masutaka.

:: Fukuoka igaku zasshi = Hukuoka acta medica, 巻 105, 番号 8, 01.08.2014, p. 166-173.

研究成果: ジャーナルへの寄稿記事

Mitoma, C, Nakahara, T, Hiroshi, U, Ito, T, inatomi, Y, Ide, T, Jinnai, S, Jinnai, N, Zeze, N, Sakamoto, K, kimura, N, Maeda, A, Kuma, Y, Maehara, E, Tsutsumi, M, Kido-Nakahara, M, Hirota, T, Tamari, M & Furue, M 2014, 'Preferential expression of OVOL1 in inner root sheath of hair, sebaceous gland, eccrine duct and their neoplasms in human skin', Fukuoka igaku zasshi = Hukuoka acta medica, 巻. 105, 番号 8, pp. 166-173.
Mitoma, Chikage ; Nakahara, Takeshi ; Hiroshi, Uchi ; Ito, Takamichi ; inatomi, yusuke ; Ide, Takatoshi ; Jinnai, Shunichi ; Jinnai, Naomi ; Zeze, Nahoko ; Sakamoto, Keiko ; kimura, nanae ; Maeda, Ayami ; Kuma, Yuki ; Maehara, Eriko ; Tsutsumi, Midori ; Kido-Nakahara, Makiko ; Hirota, Tomomitsu ; Tamari, Mayumi ; Furue, Masutaka. / Preferential expression of OVOL1 in inner root sheath of hair, sebaceous gland, eccrine duct and their neoplasms in human skin. :: Fukuoka igaku zasshi = Hukuoka acta medica. 2014 ; 巻 105, 番号 8. pp. 166-173.
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title = "Preferential expression of OVOL1 in inner root sheath of hair, sebaceous gland, eccrine duct and their neoplasms in human skin",
abstract = "OVOL1 is an important transcription factor for epidermal keratinization, which suppresses proliferation and switches on the differentiation of keratinocytes. A recent genome-wide association study has revealed that OVOL1 is one of the genes associated with susceptibility to atopic dermatitis. Although it is known to be expressed in murine skin and hair follicles, no investigations have focused on its localization in human skin. In the present study, we thus immunolocalized the expression of OVOL1 in normal and diseased human skin. In normal human skin, OVOL1 was preferentially expressed in the suprabasal layer of the epidermis, inner root sheath of hair, mature sebocytes and the ductal portion of the eccrine glands. Compared to this, no remarkable change in the expression of OVOL1 was observed among inflammatory skin diseases. The expression of OVOL1 was evident in eccrine poroma and hidradenoma. Moreover, it was overexpressed in Bowen's disease and sebaceous adenoma, in sharp contrast to its downregulation in their more malignant counterparts, squamous cell carcinoma and sebaceous carcinoma. OVOL1 may play an important role in human skin morphogenesis and tumorigenesis.",
author = "Chikage Mitoma and Takeshi Nakahara and Uchi Hiroshi and Takamichi Ito and yusuke inatomi and Takatoshi Ide and Shunichi Jinnai and Naomi Jinnai and Nahoko Zeze and Keiko Sakamoto and nanae kimura and Ayami Maeda and Yuki Kuma and Eriko Maehara and Midori Tsutsumi and Makiko Kido-Nakahara and Tomomitsu Hirota and Mayumi Tamari and Masutaka Furue",
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AU - Mitoma, Chikage

AU - Nakahara, Takeshi

AU - Hiroshi, Uchi

AU - Ito, Takamichi

AU - inatomi, yusuke

AU - Ide, Takatoshi

AU - Jinnai, Shunichi

AU - Jinnai, Naomi

AU - Zeze, Nahoko

AU - Sakamoto, Keiko

AU - kimura, nanae

AU - Maeda, Ayami

AU - Kuma, Yuki

AU - Maehara, Eriko

AU - Tsutsumi, Midori

AU - Kido-Nakahara, Makiko

AU - Hirota, Tomomitsu

AU - Tamari, Mayumi

AU - Furue, Masutaka

PY - 2014/8/1

Y1 - 2014/8/1

N2 - OVOL1 is an important transcription factor for epidermal keratinization, which suppresses proliferation and switches on the differentiation of keratinocytes. A recent genome-wide association study has revealed that OVOL1 is one of the genes associated with susceptibility to atopic dermatitis. Although it is known to be expressed in murine skin and hair follicles, no investigations have focused on its localization in human skin. In the present study, we thus immunolocalized the expression of OVOL1 in normal and diseased human skin. In normal human skin, OVOL1 was preferentially expressed in the suprabasal layer of the epidermis, inner root sheath of hair, mature sebocytes and the ductal portion of the eccrine glands. Compared to this, no remarkable change in the expression of OVOL1 was observed among inflammatory skin diseases. The expression of OVOL1 was evident in eccrine poroma and hidradenoma. Moreover, it was overexpressed in Bowen's disease and sebaceous adenoma, in sharp contrast to its downregulation in their more malignant counterparts, squamous cell carcinoma and sebaceous carcinoma. OVOL1 may play an important role in human skin morphogenesis and tumorigenesis.

AB - OVOL1 is an important transcription factor for epidermal keratinization, which suppresses proliferation and switches on the differentiation of keratinocytes. A recent genome-wide association study has revealed that OVOL1 is one of the genes associated with susceptibility to atopic dermatitis. Although it is known to be expressed in murine skin and hair follicles, no investigations have focused on its localization in human skin. In the present study, we thus immunolocalized the expression of OVOL1 in normal and diseased human skin. In normal human skin, OVOL1 was preferentially expressed in the suprabasal layer of the epidermis, inner root sheath of hair, mature sebocytes and the ductal portion of the eccrine glands. Compared to this, no remarkable change in the expression of OVOL1 was observed among inflammatory skin diseases. The expression of OVOL1 was evident in eccrine poroma and hidradenoma. Moreover, it was overexpressed in Bowen's disease and sebaceous adenoma, in sharp contrast to its downregulation in their more malignant counterparts, squamous cell carcinoma and sebaceous carcinoma. OVOL1 may play an important role in human skin morphogenesis and tumorigenesis.

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