Preferential M2 macrophages contribute to fibrosis in IgG4-related dacryoadenitis and sialoadenitis, so-called Mikulicz's disease

Sachiko Furukawa, Masafumi Moriyama, Akihiko Tanaka, takashi maehara, Hiroto Tsuboi, Mana Iizuka, Hayashida Jun-Nosuke, Miho Ohta, Takako Saeki, Kenji Notohara, Takayuki Sumida, Seiji Nakamura

研究成果: ジャーナルへの寄稿記事

46 引用 (Scopus)

抄録

IgG4-related dacryoadenitis and sialoadenitis (IgG4-DS) is characterized by bilateral swelling of glandular tissues with extensive fibrosis, and is immunologically considered a Th2-predominant disease. Recent studies reported that alternatively activated (M2) macrophages enhanced Th2 immune responses and fibrosis by production of pro-fibrotic factors (IL-10, IL-13 and CCL18). Therefore, we examined the association between M2 macrophages and fibrosis in submandibular glands from 7 patients with IgG4-DS, 10 patients with chronic sialoadenitis, 10 patients with Sjögren's syndrome, and 10 healthy subjects. The number of M2 macrophages in SMGs from patients with IgG4-DS was also significantly higher than in the other groups. Double immunofluorescence staining showed that IL-10 and CCL18 expression co-localized with M2 macrophage-marker (CD163). Furthermore, the SMG fibrosis score was positively correlated with the frequency of M2 macrophages in only IgG4-DS. These results indicate that IL-10 and CCL18 secreted by preferential M2 macrophages possibly play a key role in the development of severe fibrosis in IgG4-DS.

元の言語英語
ページ(範囲)9-18
ページ数10
ジャーナルClinical Immunology
156
発行部数1
DOI
出版物ステータス出版済み - 1 1 2015

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Mikulicz' Disease
Dacryocystitis
Sialadenitis
Fibrosis
Immunoglobulin G
Macrophages
Interleukin-10
Interleukin-13
Submandibular Gland
Fluorescent Antibody Technique
Healthy Volunteers
Staining and Labeling

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

これを引用

Preferential M2 macrophages contribute to fibrosis in IgG4-related dacryoadenitis and sialoadenitis, so-called Mikulicz's disease. / Furukawa, Sachiko; Moriyama, Masafumi; Tanaka, Akihiko; maehara, takashi; Tsuboi, Hiroto; Iizuka, Mana; Jun-Nosuke, Hayashida; Ohta, Miho; Saeki, Takako; Notohara, Kenji; Sumida, Takayuki; Nakamura, Seiji.

:: Clinical Immunology, 巻 156, 番号 1, 01.01.2015, p. 9-18.

研究成果: ジャーナルへの寄稿記事

Furukawa, Sachiko ; Moriyama, Masafumi ; Tanaka, Akihiko ; maehara, takashi ; Tsuboi, Hiroto ; Iizuka, Mana ; Jun-Nosuke, Hayashida ; Ohta, Miho ; Saeki, Takako ; Notohara, Kenji ; Sumida, Takayuki ; Nakamura, Seiji. / Preferential M2 macrophages contribute to fibrosis in IgG4-related dacryoadenitis and sialoadenitis, so-called Mikulicz's disease. :: Clinical Immunology. 2015 ; 巻 156, 番号 1. pp. 9-18.
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abstract = "IgG4-related dacryoadenitis and sialoadenitis (IgG4-DS) is characterized by bilateral swelling of glandular tissues with extensive fibrosis, and is immunologically considered a Th2-predominant disease. Recent studies reported that alternatively activated (M2) macrophages enhanced Th2 immune responses and fibrosis by production of pro-fibrotic factors (IL-10, IL-13 and CCL18). Therefore, we examined the association between M2 macrophages and fibrosis in submandibular glands from 7 patients with IgG4-DS, 10 patients with chronic sialoadenitis, 10 patients with Sj{\"o}gren's syndrome, and 10 healthy subjects. The number of M2 macrophages in SMGs from patients with IgG4-DS was also significantly higher than in the other groups. Double immunofluorescence staining showed that IL-10 and CCL18 expression co-localized with M2 macrophage-marker (CD163). Furthermore, the SMG fibrosis score was positively correlated with the frequency of M2 macrophages in only IgG4-DS. These results indicate that IL-10 and CCL18 secreted by preferential M2 macrophages possibly play a key role in the development of severe fibrosis in IgG4-DS.",
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AU - Sumida, Takayuki

AU - Nakamura, Seiji

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