PRELIMINARY OBSERVATION ON PANCREATIC DUCT ADENOCARCINOMA INDUCED BY INTRADUCTAL ADMINISTRATION OF N‐ETHYL‐N′ ‐NITRO‐N‐NITROSOGUANIDINE IN DOGS

Toshiki Kamano, Noboru Azuma, Atsuo Katami, Junji Tamura, Noburu Sakakibara, Michio Matsumoto, Kazuhiro Mizumoto, Shunji Kitazawa, Yoichi Konishi

研究成果: Contribution to journalArticle査読

10 被引用数 (Scopus)

抄録

Pancreatic duct adenocarcinoma was induced by intraductal administration of N‐ethyl‐N′‐nitro N‐nitrosoguanidine (ENNG) in two mongrel dogs. A dog received a total dose of 595 mg of ENNG during 12 months and was sacrificed. Duct obstruction was detected by pancreatography and duct adenocarcinoma was found. Another dog was given a total dose of 350 mg of ENNG during 8 months and was sacrificed 26 months after the first administration of the carcinogen. Duct adenocarcinoma was found. No pancreatic tumors were found in 2 dogs given intraperitoneal N‐nitrosobis(2‐oxo‐propyl)amine at a total dose of 4000 mg or in 2 dogs given Tween 60 only. These results suggest that the direct presence of a carcinogen in the pancreatic duct was able to induce duct adenocarcinoma in dogs.

本文言語英語
ページ(範囲)1-4
ページ数4
ジャーナルJapanese Journal of Cancer Research
79
1
DOI
出版ステータス出版済み - 1 1988
外部発表はい

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

フィンガープリント 「PRELIMINARY OBSERVATION ON PANCREATIC DUCT ADENOCARCINOMA INDUCED BY INTRADUCTAL ADMINISTRATION OF N‐ETHYL‐N′ ‐NITRO‐N‐NITROSOGUANIDINE IN DOGS」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

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