TY - JOUR
T1 - Preload sensitivity in cardiac assist devices
AU - Fukamachi, Kiyotaka
AU - Shiose, Akira
AU - Massiello, Alex
AU - Horvath, David J.
AU - Golding, Leonard A.R.
AU - Lee, Sangjin
AU - Starling, Randall C.
N1 - Funding Information:
This study was partly supported by Grant R01 HL096619-01 (principal investigator L. Golding), awarded by the National Heart, Lung, and Blood Institute .
PY - 2013/1
Y1 - 2013/1
N2 - With implantable cardiac assist devices increasingly proving their effectiveness as therapeutic options for end-stage heart failure, it is important for clinicians to understand the unique physiology of device-assisted circulation. Preload sensitivity as it relates to cardiac assist devices is derived from the Frank-Starling relationship between human ventricular filling pressures and ventricular stroke volume. In this review, we stratify the preload sensitivity of 17 implantable cardiac assist devices relative to the native heart and discuss the effect of preload sensitivity on left ventricular volume unloading, levels of cardiac support, and the future development of continuous-flow total artificial heart technology.
AB - With implantable cardiac assist devices increasingly proving their effectiveness as therapeutic options for end-stage heart failure, it is important for clinicians to understand the unique physiology of device-assisted circulation. Preload sensitivity as it relates to cardiac assist devices is derived from the Frank-Starling relationship between human ventricular filling pressures and ventricular stroke volume. In this review, we stratify the preload sensitivity of 17 implantable cardiac assist devices relative to the native heart and discuss the effect of preload sensitivity on left ventricular volume unloading, levels of cardiac support, and the future development of continuous-flow total artificial heart technology.
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U2 - 10.1016/j.athoracsur.2012.07.077
DO - 10.1016/j.athoracsur.2012.07.077
M3 - Review article
C2 - 23272869
AN - SCOPUS:84871859868
VL - 95
SP - 373
EP - 380
JO - Annals of Thoracic Surgery
JF - Annals of Thoracic Surgery
SN - 0003-4975
IS - 1
ER -